Dennis P. Curran
Department of Chemistry
University of Pittsburgh

Functionally tethered oligodeoxynucleotides are critical precursors for the preparation of new hybrid DNA molecules. The installation of a "convertible nucleoside" into a synthetic oligodeoxynucleotide now permits the synthesis of a whole series of functionally tethered oligodeoxynucleotides from a single precursor.

A.M. MacMillan, G.L. Verdine, "Synthesis of functionally tethered oligodeoxynucleotides by the convertible nucleoside approach," Journal of Organic Chemistry, 55, 5931-3, 23 November 1990. (Harvard University, Cambridge, Mass.)

It is not often that an entire issue of a respected journal is dedicated to a single article. Moreover, a full paper is presented (with complete experimental, physical, and spectral details) describing a landmark synthesis that was completed and communicated three decades ago! All research should make such informative reading 30 years afterward.

R.B. Woodward, W.A. Ayer, J.M. Beaton, F. Bickelhaupt, et al., "The total synthesis of chlorophyll a," Tetrahedron, 46 (22), 7599-659,...

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