Department of Microbiology & Immunology
University of Illinois
Pseudopods flowing from phagocytes and amoeba constantly assemble and disassemble actin into rods and networks. This popular review of recent progress on regulation of cellular movement is full of wonderful graphics, suitable for textbooks and teaching.
T.P. Stossel, "How cells crawl," American Scientist, 78, 408-23, September-October 1990. (Harvard Medical School and Massachusetts General Hospital, Boston)
Leishmania and Trypanosomia bring forth romantic notions of major tropical diseases in need of "magic bullets"--or, at least, vaccines, which have been slow in development. The ability to reintroduce marked genes by electroporation into the correct positions in trypanosomes does not lead immediately to cures or preventive strategies. Yet this major new ability to manipulate the genetics of these pathogens will lead there eventually.
A. Cruz, S.M. Beverley, "Gene replacement in parasitic protozoa," Nature, 348, 171-3, 8 November 1990. (Harvard Medical School, Boston)