Dennis P. Curran
Department of Chemistry
University of Pittsburgh
Pittsburgh, Pa.

Intercalation is one of the most important ways by which small molecules can interact with DNA. This timely analysis addresses a very important question: In the absence of a crystal structure, what constitutes strong experimental evidence for intercalative interactions?

E.C. Long, J.K. Barton, "On demonstrating DNA intercalation," Accounts of Chemical Research, 23, 171-3, September 1990. (California Institute of Technology, Pasadena)

Asymmetric aldol reactions promoted by organotin Lewis acids and chiral diamines previously could be conducted only on a stoichiometric basis. However, with appropriate modifications, this reaction can be rendered catalytic in both the organotin reagent and the chiral diamine. The result is a very powerful method for the synthesis of optically active syn aldol adducts.

S. Kobayashi, Y. Fujishita, T. Mukaiyama, "The efficient catalytic asymmetric aldol-type reaction," Chemistry Letters, 8, 1455-8, 1990. (Science University of Tokyo)

It is generally...

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