Dennis P. Curran
Department of Chemistry
University of Pittsburgh
Intercalation is one of the most important ways by which small molecules can interact with DNA. This timely analysis addresses a very important question: In the absence of a crystal structure, what constitutes strong experimental evidence for intercalative interactions?
E.C. Long, J.K. Barton, "On demonstrating DNA intercalation," Accounts of Chemical Research, 23, 171-3, September 1990. (California Institute of Technology, Pasadena)
Asymmetric aldol reactions promoted by organotin Lewis acids and chiral diamines previously could be conducted only on a stoichiometric basis. However, with appropriate modifications, this reaction can be rendered catalytic in both the organotin reagent and the chiral diamine. The result is a very powerful method for the synthesis of optically active syn aldol adducts.
S. Kobayashi, Y. Fujishita, T. Mukaiyama, "The efficient catalytic asymmetric aldol-type reaction," Chemistry Letters, 8, 1455-8, 1990. (Science University of Tokyo)
It is generally...