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BY SIMON SILVER Department of Microbiology & Immunology University of Illinois Chicago, Ill " Berkeley virologist Peter Duesberg has carried out a campaign questioning whether the HIV retrovirus is the etiological agent of AIDS. A previous expression of Duesberg’s views appeared in Science (241, 5 14-17, 29 July 1988); a recent article presents the latest version of his arguments against H1V as the agent of AIDS. P.H. Duesberg, “Human immunodeficiency virus and acquired immunodefic

Simon Silver

BY SIMON SILVER Department of Microbiology & Immunology University of Illinois Chicago, Ill

" Berkeley virologist Peter Duesberg has carried out a campaign questioning whether the HIV retrovirus is the etiological agent of AIDS. A previous expression of Duesberg’s views appeared in Science (241, 5 14-17, 29 July 1988); a recent article presents the latest version of his arguments against H1V as the agent of AIDS. P.H. Duesberg, “Human immunodeficiency virus and acquired immunodeficiency syndrome: correlation but not causation,”

Proceedings of the National Academy of Sciences, USA, 86(3), 755-64, February 1989.

" The multidrug resistance system in tumor cells consists of a remarkable 170,000 molecular weight glycoprotein. Cells containing this membrane ATPase “flush out” toxic compounds of diverse structures. The wide substrate range and complex structure of the ATPase with two membrane sections and two ATPase domains raise interesting questions as to its origin and function.

N. Kartner, V....

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