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CHEMISTRY BY MARYE ANNE FOX Department of Chemistry University of Texas, Austin Austin, Tex. " Effective planning of strategy represents the most important intellectual attainment of synthetic organic chemistry. One of the masters has provided an overview in a recently published Robert Robinson lecture. E.J. Corey, “Retrosynthetic thinking, Essentials and exam- pels," Chemical Society Reviews, 17 (2), 111-34, June 1988. " The ability to cleave DNA at will at a specific position is a m

Marye Anne Fox
Dec 25, 1988

CHEMISTRY

BY MARYE ANNE FOX
Department of Chemistry
University of Texas, Austin
Austin, Tex.

" Effective planning of strategy represents the most important intellectual attainment of synthetic organic chemistry. One of the masters has provided an overview in a recently published Robert Robinson lecture.

E.J. Corey, “Retrosynthetic thinking, Essentials and exam- pels," Chemical Society Reviews, 17 (2), 111-34, June 1988.

" The ability to cleave DNA at will at a specific position is a major intermediate goal necessary for rational genetic engineering. A new article reports the synthesis of a protein consisting wholly of naturally occurring amino acids with two structural domains having distinct functions: sequence-specific recognition and cleavage of double helical DNA.

D.P. Mack, B.L Iverson, P.R. Dervan, “Design and chemical synthesis of a sequence-specific DNA-cleaving protein,” Journal of the American Chemical Society, 110 (22), 7572-4, 26 October 1988.

" Matter with structural complexity...

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