BY MARYE ANNE FOX
Department of Chemistry
University of Texas, Austin
" Effective planning of strategy represents the most important intellectual attainment of synthetic organic chemistry. One of the masters has provided an overview in a recently published Robert Robinson lecture.
E.J. Corey, “Retrosynthetic thinking, Essentials and exam- pels," Chemical Society Reviews, 17 (2), 111-34, June 1988.
" The ability to cleave DNA at will at a specific position is a major intermediate goal necessary for rational genetic engineering. A new article reports the synthesis of a protein consisting wholly of naturally occurring amino acids with two structural domains having distinct functions: sequence-specific recognition and cleavage of double helical DNA.
D.P. Mack, B.L Iverson, P.R. Dervan, “Design and chemical synthesis of a sequence-specific DNA-cleaving protein,” Journal of the American Chemical Society, 110 (22), 7572-4, 26 October 1988.
" Matter with structural complexity...