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CHEMISTRY BY RON MAGOLDA Medical Products Department E.I. du Pont de Nemours & Co. Wilmington, Del. " Strategies to control H1V-1 replication are being intensively investigated. A promising approach has been described using oligonucleoside phosphoramidates and phosphorothioates as antivitral agents. S. Argawal, J. Goodchild, M.P. Civeira, A.H. Thornton, P.S. Sam, P.C. Zamecnik, "Oligonucleoside phosphoramidates and phosphorothiostes as inhibitors of human immunodeficiency virus," Proceeding

Ron Magolda
Nov 27, 1988

CHEMISTRY

BY RON MAGOLDA
Medical Products Department
E.I. du Pont de Nemours & Co.
Wilmington, Del.

" Strategies to control H1V-1 replication are being intensively investigated. A promising approach has been described using oligonucleoside phosphoramidates and phosphorothioates as antivitral agents.

S. Argawal, J. Goodchild, M.P. Civeira, A.H. Thornton, P.S. Sam, P.C. Zamecnik, "Oligonucleoside phosphoramidates and phosphorothiostes as inhibitors of human immunodeficiency virus," Proceedings of the National Academy of Sciences of the USA, 85 (19), 7079-83, October 1988.

" The design of specific synthetic receptors is of growing interest in bioorganic chemistry. A new paper reports how a synthetic receptor was designed to recognize and transport across a chloroform interface adenine derivatives.

T. Benzing, T. Tjivikua, J. Wolfe, J. Rebek, "Recognition and transport of adenine derivatives with synthetic receptors," Science, 242 (4876), 206-8, 14 October 1988.

" New synthetic methodology that affords facile preparation of polycyclic amines and...

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