Department of Biology
University of California, San Diego
La Jolla, Calif.

" GAL4, a yeast transcriptional activator, stimulates transcription of genes if it binds nearby, but it squelches genes to which it cannot bind. It appears that high levels of GALA sequester another common transcription factor.

G. Gill, M. Ptashne, “Negative effect of the transcriptional activator GAL4,” Nature, 334 (6184), 721-4,25 August 1988.

" Dominant mutations that result in loss of responsiveness to the plant regulator ethylene have been isolated and mapped to chromosome 1 in Arizbidopsis thaliana. Mutant plants are delayed in flowering, and the seeds germinate poorly, but neither growth nor development is drastically altered.

A.B. Bleecker, MA. Estelle, C. Somerville, “Insensitivity to ethylene conferred by a dominant mutation in Arabidopsi.s thaliana,” Science, 241 (4869), 1086-9,26 August 1988.

" The problem of predicting secondary structures of proteins from their amino acid sequences remains...

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