BY RON MAGOLDA
Medical Products Department
E.I. du Pont de Nemours & Co.
A highly convergent and efficient route to the synthetically useful dihydropyrancarboxylates has been identified.
L.F Tietze, H. Meier, H. Nutt, “The tandem Knoevenagel hetero Diels-Alder reaction with a formylacetic acid equivalent. Synthesis of dihydropyrancarboxylates,” Chemische Berichte, 122, 643-50, April 1989. (Institut für Organische Chemie der Universität Gottingen, F.R.G.)
The excitement of catalytic antibodies or “abzymes” continues to grow with the recent discovery of enantioselective antibodies. This latest extension offers a novel set of practical reagents.
K.D. Janda, SJ. Benkovic, R.A. Lamer, “Catalytic antibodies with lipase activity and R or S substrate selectivity,” Science, 244, 437-40, 28 April 1989. (Research Institute of Scripps Clinic, La Jolla, Calif.; Pennsylvania State University, University Park, Pa.)
An attractive general method of enzyme-activated inhibition recently has been presented.
S. Halazy, C. Danzin, A. Ehrhard, F...