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Chemistry

Ron Magolida Medical Products Department E.I. du Pont de Nemours & Co. Wilmington, Del. The biosynthesis and inhibition of prostacyclin and thromboxane A2 has for almost two decades attracted tremendous interest in both the biological and chemical community. A recent paper presents evidence for the biosynthesis of these important biomolecules via a cage radical mechanism. M. Hecker, V. Ullrich, "On the mechanism of prostacyclin and thromboxane A2 biosynthesis," Journal of Biological Chemistr

The Scientist Staff

Ron Magolida
Medical Products Department E.I. du Pont de Nemours & Co.
Wilmington, Del.

The biosynthesis and inhibition of prostacyclin and thromboxane A2 has for almost two decades attracted tremendous interest in both the biological and chemical community. A recent paper presents evidence for the biosynthesis of these important biomolecules via a cage radical mechanism.

M. Hecker, V. Ullrich, "On the mechanism of prostacyclin and thromboxane A2 biosynthesis," Journal of Biological Chemistry, 264 (1), 141-150, 5 January 1989.

" An efficient and practical intramolecular photochemical approach for the preparation of nitrogen heterocycles has been identified.

W. Xu, Y.T. Jeon, E. Hasegawa, U.C. Yoon, P.S. Mariano, "Novel electron-transfer photocyclization reactions of alpha-silyl amine alpha, beta-unsaturated ketone and ester systems," Journal of the American Chemical Society, 111 (1), 406-8, 4 January 1989.

" Three new compounds with antibiotic activity have been isolated from a plant source.

H. Jayasuriya, J.D....

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