Everything in Moderation... Even Tumor Suppressors

The Faculty of 1000, published by BioMed Central, is a Web-based literature awareness tool. F1000 provides a continuously updated guide to peer-reviewed papers, based on the recommendations of more than 1,400 leading scientists. In each issue, The Scientist publishes a review of some related papers highlighted by the Faculty of 1000, plus comments on new and notable research. For more information, visit www.facultyof1000.com. Homeostasis is an arguably underappreciated and powerful process t

Susan Jenkins
May 26, 2002
The Faculty of 1000, published by BioMed Central, is a Web-based literature awareness tool. F1000 provides a continuously updated guide to peer-reviewed papers, based on the recommendations of more than 1,400 leading scientists.

In each issue, The Scientist publishes a review of some related papers highlighted by the Faculty of 1000, plus comments on new and notable research. For more information, visit www.facultyof1000.com.
Homeostasis is an arguably underappreciated and powerful process that may yet receive its due, as scientists continue to knock out, mutate, and overexpress genes to clarify protein function. It is clear that these techniques contribute greatly to the understanding of life at the cellular, tissue, organ, and organismal level. However, models created with less potent functional dysregulation may mimic more accurately real-world physiology.

Two groups of researchers have isolated functional truncated mutant forms of p53 with a wild-type allele in two different model systems, worm and...

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