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1992'S HOTTEST RESEARCH PAPERS RANK PAPER CITATIONS 1 M. Leid, et al., "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently," Cell, 68(2): 377- 95, 24 January 1992. 58 2 J.D. Brook, et al., "Molecular basis of myotonic dystrophy; Expansion of a trinucleotide (CTG) repeat at the 3 end of a transcript encoding a protein kinase family member," Cell, 68(4):799-808, 20 February 1992. 47 3 W.O. Spitzer, et al., "The use of beta-agonists and the risk of death and near death from asthma," NEJM, 326(8):501-6, 20 February 1992. 42 4 H.G. Harley, et al., "Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy," Nature, 355(6360):545-6, 6 February 1992. 41 5 T.E. Golde, et al., "Processing of the amyloid protein precursor to potentially amyloidogenic derivatives," Science, 255(5045):728-30, 7 February 1992. 41 6 C.E. Bear, et al., "Purification and and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)," Cell, 68(4):809-18, 21 February 1992. 39 7 C. Aslanidis, et al., "Cloning of the essential myotonic dystrophy region and mapping of the putative defect," Nature, 355(6360):548-51, 6 February 1992. 39 8 J. Buxton, et al., "Detection of an unstable fragment of DNA specific to individuals with myotonic dystrophy," Nature, 355(6360):547-8, 6 February 1992. 37 9 Y. Tanabe, et al., "A family of metabotropic glutamate receptors," Neuron, 8(1):169-79, January 1992. 36 10 F. Abe, et al., "Lower limit on the top-quark mass from events with two leptons in pp collisions at = 1.8 TeV," Phys. Rev. Lett., 68(4):447-51, 27 January 1992. 35 11 R.A. Heyman, et al., "9-Cis retinoic acid is a high affinity ligand for the retinoid X receptor," Cell, 68(2):397-406, 24 January 1992. 33 12 Y.-H. Fu, et al., "An unstable triplet repeat in a gene related to myotonic muscular dystrophy," Science, 255(5049):1256-8, 6 March 1992. 31 13 K.W. Wood, et al., "ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK," Cell, 68(6):1041- 50, 20 March 1992. 28 14 H.Y. Lin, et al., "Expression cloning of the TGF-beta Type II receptor, a function transmembrane serine/ threonine kinase," Cell, 68(4):775-85, 21 February 1992. 27 15 M.D. Adams, et al., "Sequence identification of 2,375 human brain genes," Nature, 355(6361):632-4, 13 February 1992. 27 16 S. Matsuda, et al., "Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade," EMBO J., 11(3):973-82, March 1992. 27 17 M. Mahadevan, et al., "Myotonic dystrophy mutation: an unstable CTG repeat in the 3 untranslated region of the gene," Science, 255(5049):1253-5, 6 March 1992. 26 18 Q.-W. Xie, et al., "Cloning and characterization of inducible nitric oxide synthase from mouse macrophages," Science, 256(5054):225-8, 10 April 1992. 25 19 A.D. Federman, et al., "Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits," Nature, 356(6365):159-61, 12 March 1991. 24 20 L.A. Donehower, et al., "Mice deficient for the p53 are developmentally normal but susceptible to spontaneous tumours," Nature, 356(6366):215-21, 19 March 1992. 24 21 W.I.F. David, et al., "Structural phase transitions in the fullerene C60," Europhys. Lett., 18(3):219-225, 21 February 1992. 24 22 M.S. Brandt, et al., "The origin of visible luminescence from `porous silicon': a new interpretation," Solid State Comm., 81(4):307-12, January 1992. 23 23 C.R. Lyons, G.J. Orloff, J. M. Cunningham, "Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line," J. Biol. Chem., 267(9):6370-4, 25 March 1992. 23 24 S.M. Thomas, et al., "Ras is essential for nerve growth factor and phorbol ester-induced tyrosine phosphorylation of MAP kinases," Cell, 68(6):1031-40, 20 March 1992. 22 25 C.T. Baldwin, et al., "An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome," Nature, 355(6361):637-8, 13 February 1992. 22 26 M.P. Mattson, et al., "Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity," J. Neurosci., 12(2):376- 89, February 1992. 21 27 W.J. Fanti, et al., "Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways," Cell, 69(3):413- 23, 1 May 1992. 21 28 D.P. Gearing, et al., "The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity coverter for the LIF receptor," Science, 255(5050): 1434-7, 13 March 1992. 21 29 C.A. Midgley, et al., "Analysis of p53 expression in human tumors: an antibody raised against human p53 expressed in Escherichia coli," J. Cell. Sci., 101(1):183-9, January 1992. 21 30 A. Kashishian, A. Kazlauskas, J.A. Cooper, "Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo," EMBO J., 11(4):1373-82, April 1992. 20 31 S. Dalton, R. Treisman, "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element," Cell, 68(3):597-612, 7 February 1992. 20 SOURCE: Science Watch/Institute for Scientific Information

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