Hot Papers

The following is a list of the 13 papers on cell cycle biology featured in The Scientist's "Hot Papers" column during the past year. Brief summaries of the papers are included. * G. Draetta, D. Beach, "Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement," Cell, 54, 17-26, 1 July 1988. (128 citations*; Jan. 8, 1990**) In this paper, Beach and Draetta demonstrated the first evidence of the involvement in mitosis of the

The Scientist Staff
Dec 9, 1990

The following is a list of the 13 papers on cell cycle biology featured in The Scientist's "Hot Papers" column during the past year. Brief summaries of the papers are included.

* G. Draetta, D. Beach, "Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement," Cell, 54, 17-26, 1 July 1988. (128 citations*; Jan. 8, 1990**)

In this paper, Beach and Draetta demonstrated the first evidence of the involvement in mitosis of the human homolog to yeast cdc2 protein kinase. Also, phosphorylation of human cdc2 protein kinase brings about an association with a second protein.

* W.G. Dunphy, L. Brizuela, D. Beach, J. Newport, "The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis," Cell, 54, 423-31, 29 July 1988. (167 citations; Jan. 8, 1990)

J. Gautier, C. Norbury, M. Lohka, P. Nurse, J. Maller, "Purified maturation-promoting factor contains...