Likening his discovery to a paleontologist unearthing a new dinosaur species, Vladimir Kapitonov, a staff scientist at the Genetic Information Research Institute, recently revealed a new class of transposable elements in eukaryotes. These jumping genes use rolling circle replication--an ancient process characteristic of some plasmid replication in bacteria--to copy and insert itself throughout entire genomes (V.V. Kapitonov, J. Jurka, "Rolling circle transposons in eukaryotes," Proceedings of the National Academy of Sciences, 98:8714-9 July 17, 2001.) Found in the genomes of Arabidopsis thaliana, Oriza sativa, and Caenorhabditis elegans, these elements have been dubbed helitrons because nearly always they code for a helicase, which unwinds the double helix at both the original transposon and the integration site. Through computational analysis of variation in transposons, which in Arabidopsis and nematodes constitute roughly 2 percent of genomic DNA, Kapitonov estimates that helitrons are tens of millions years old. The origin and...
Interested in reading more?
Become a Member of
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?