RNA Calls the Shots

Courtesy of Vasudeva Mahavisno  CANCER CARTOGRAPHY: Metastatic prostate cancer from a tissue array stained for EZH2 protein. The background represents gene expression signatures of prostate cancer as a heat map, which lead to the discovery of EZH2 as a prostate cancer biomarker. As soon as Watson and Crick deduced DNA's structure half a century ago, their thoughts turned to RNA. Arguably the most important molecule in the living world, RNA not only connects gene to protein, but its catal

Ricki Lewis
Feb 23, 2003
Courtesy of Vasudeva Mahavisno
 CANCER CARTOGRAPHY: Metastatic prostate cancer from a tissue array stained for EZH2 protein. The background represents gene expression signatures of prostate cancer as a heat map, which lead to the discovery of EZH2 as a prostate cancer biomarker.

As soon as Watson and Crick deduced DNA's structure half a century ago, their thoughts turned to RNA. Arguably the most important molecule in the living world, RNA not only connects gene to protein, but its catalytic capability inspired the idea of an "RNA world," where the single-stranded nucleic acid, or something like it, enabled chemistry to become biology. Today, RNA is still revealing its secrets.

Recent reports indicate that there's more to the informational content of a messenger RNA (mRNA) than the mere mirror of a gene's DNA base sequence. These eclectic molecules interact directly with metabolites, control the levels of other transcripts just by their own...

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