Sidebar: For More Information - Caloric Restriction's BenefitsCaloric restriction (CR) research has come a long way since Cornell University nutritionist Clyde McCay published a ground-breaking 1935 paper that showed that rats on calorically restricted, nutritionally sound diets lived longer than rats that were allowed to eat as much as they wanted (C.J. McCay, Journal of Nutrition, 10:63-79, 1935). Some 50 years of research since has confirmed that finding. In general, experimental animals fed about 30 percent less than controls allowed to eat as much as they want achieve an increase of about 40 percent in maximum life span. It has also been shown that CR retards or eliminates various chronic disorders, such as cancer, diabetes, and renal disease, and improves immune system function in lab animals (E. Masaro, American Journal of Clinical Nutrition, 55:1250S-52S, 1992).
Today, the National Institute on Aging (NIA) supports CR research...
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