|Credit: Eric Laywell|
An astrocyte monolayer that can be coaxed into becoming multipotent neural stemlike cells
"All politics is local" was a famous maxim of Thomas "Tip" O'Neill, the late speaker of the House of Representatives, and the same can be said of medically useful stem cells. Progenitor cells may prove to be more or less pluripotent in the lab, but if they don't succeed on a local level in the body, they won't cure anything. They must be capable of being coaxed into differentiating reliably into the cell types that populate particular organs.
How much can embryonic stem cells (ESCs) and adult stem cells (ASCs) replenish tissues of the brain, pancreas, liver, heart, and blood? So far, researchers have manipulated ESCs to...