The COX Continuum

Adapted from T.D. Warner et al., Proc Natl Acad Sci, 99:13371-3, 2002. SLIDING SCALE: Two distinct genes for COX-1 and -2 may give rise to a number of constitutive and inducible COX proteins with overlapping functions. The discovery of cyclooxygenase (COX) isoforms, COX-1 and COX-2, in the early 1990s helped explain how non-steroidal anti-inflammatory drugs (NSAIDs) work and led to specific agents with fewer gastrointestinal side effects. Last year, Brigham Young University researchers c

Mark Greener
Jul 13, 2003
Adapted from T.D. Warner et al., Proc Natl Acad Sci, 99:13371-3, 2002.
 SLIDING SCALE: Two distinct genes for COX-1 and -2 may give rise to a number of constitutive and inducible COX proteins with overlapping functions.

The discovery of cyclooxygenase (COX) isoforms, COX-1 and COX-2, in the early 1990s helped explain how non-steroidal anti-inflammatory drugs (NSAIDs) work and led to specific agents with fewer gastrointestinal side effects. Last year, Brigham Young University researchers characterized another isoform, COX-3, which may constitute part of acetaminophen's long sought-after mode of action.1 The study also suggests that a continuum of COX protein products could contribute to common inflammatory disease symptoms and may lead to a new generation of anti-inflammatory drugs.

For 3,500 years, traditional healers used plants containing salicylates. Bayer introduced acetyl-salicylic acid (Aspirin) in 1899, but NSAIDs' mode of action remained a mystery. Then, in 1971, British Nobel Prize winner John...

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