The Secret Lives of Proteins
Recent research suggests that many structural and enzymatic proteins serve double or even triple duty (see Enzymatic Alter-Egos Unmasked). Three multifunctional proteins identified in higher animals are shown below.
©2003 American Society for Biochemistry & Molecular Biology
- In neurons, forms a scaffold that stabilizes inhibitory neurotransmitter receptors by anchoring them to the cytoskeleton
- Involved in synthesizing the molybdenum cofactor (Moco), a crucial component of certain enzymes that catalyze redox reactions
- May regulate translational machinery synthesizing proteins in dendrites
- May link neurotransmitter receptors to intracellular signaling proteins that regulate long-term synaptic changes (which underlie learning and memory)
Wiskott-Aldrich Syndrome Protein (WASP)