Unraveling The Biochemistry of Fat Metabolism
Biochemical InterestBelieved MechanismPotential Drug Leptin receptorWhen mutated, resists leptin bindingRepairs receptor; creates tailored leptin-like molecule Neuropeptide YStimulates carbohydrate cravingNPY antagonist GalaninStimulates fat intake and lowers insulin levelGalanin antagonist CholecystokininSignals brain to stop eatingCCK agonist DopamineSignals brain to stop eatingDopamine/fatty acid combination drug
The Scientist Staff
Sep 15, 1996
| Biochemical Interest | Believed Mechanism | Potential Drug |
|---|---|---|
| Leptin receptor | When mutated, resists leptin binding | Repairs receptor; creates tailored leptin-like molecule |
| Neuropeptide Y | Stimulates carbohydrate craving | NPY antagonist |
| Galanin | Stimulates fat intake and lowers insulin level | Galanin antagonist |
| Cholecystokinin | Signals brain to stop eating | CCK agonist |
| Dopamine | Signals brain to stop eating | Dopamine/fatty acid combination drug |
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