Venerable Papers: Ten Classic Articles Over 50 Years Old

When considered today, most papers written prior to 1940 - when the structure of DNA was not yet known, and even before DNA was shown to be the medium of genetic inheritance - seem relics from science's "antediluvian" period. In the past 50 years, there has been a flood of discoveries in virtually every field of science, and as the pace of research accelerates, papers are aging ever more rapidly. RANK PAPER CITATIONS 1. C.H. Fiske, Y. SubbaRow, "The colorimetric determination of phosphor

David Pendelbury
Jan 19, 1990

When considered today, most papers written prior to 1940 - when the structure of DNA was not yet known, and even before DNA was shown to be the medium of genetic inheritance - seem relics from science's "antediluvian" period. In the past 50 years, there has been a flood of discoveries in virtually every field of science, and as the pace of research accelerates, papers are aging ever more rapidly.

RANK PAPER CITATIONS
1. C.H. Fiske, Y. SubbaRow, "The colorimetric determination of phosphorus," J. Biol. Chem., 66:375-400, 1925 17,217
2. H. Lineweaver, D. Burk, "The determination of enzyme dissociation constants," J. Amer. Chem. Soc., 56:658-66, 1934 9,375
3. L.J. Reed, H. Muench, "A simple method of estimating fifty per cent endpoints," Amer. J. Hygiene, 27:493-7, 1938 7,797
4. H.A. Krebs, K. Henseleit, "Untersuchungen uber die harnstoffbildung im tierkorper (Studies on urea formation in mammals)," Hoppe-Seylers...