As a child, Doris Tsao spent long hours musing on the mechanics and philosophy of vision with her father, who owns a company that designs artificial vision systems. "He made vision seem like the greatest scientific problem," she says. By the time Tsao was 11 or 12, she'd been hit by "the realization that your sense of vision is created by your brain" - and her fate as a brain researcher was sealed.
Tsao studied biology and math as an undergraduate at the California Institute of Technology, and in 1996 began her doctorate at Harvard Medical School, working on stereopsis (depth perception) with vision neuroscientist Margaret Livingstone. Researchers were just beginning to use functional MRI to study maps of human brain activation, and Livingstone sent Tsao to Massachusetts General Hospital to work with fMRI expert Roger Tootell and establish the technique in monkeys. Tsao thought...
Tsao began with stereopsis, but soon moved on to a topic that had also captured her imagination. In 1997, then Harvard University researcher Nancy Kanwisher used fMRI to identify a human cortical area specialized for face recognition. It wasn't clear, though, whether monkeys had such a dedicated module: Single-neuron studies had suggested that their face cells were scattered throughout the temporal cortex.
In 2003, Tsao and Winrich Freiwald, a monkey electrophysiologist and at the time a postdoc with Kanwisher (now at MIT), identified face-selective patches in monkeys using fMRI.
"It's lovely when someone takes a whole history of the field and says, 'No, it's not quite like you think it is,' and twists it back around" to present a new view, says Livingstone. In 2004, the Alexander von Humboldt Foundation awarded Tsao €900,000 to start a lab in Germany, and in 2006 she moved to the University of Bremen, where Freiwald was already working. The duo went on to identify six distinct cortical regions involved in face processing, each containing neurons with characteristically different firing patterns.
Next year, Tsao will return to Caltech as an assistant professor in biology. She intends to return to stereopsis and other aspects of 3- dimensional vision, but there's no turning back with her work on face processing. Already, says Freiwald, "We are opening all these possibilities - almost too many for us to study them all."
Title: Head of Independent Research Group, Brain Research Institute, University of Bremen, Germany
1. D.Y. Tsao et al., "Faces and objects in macaque cerebral cortex," Nat Neurosci, 6:989-95, 2003. (Cited in 74 papers) 2. D.Y. Tsao et al., "A cortical region consisting entirely of face-selective cells," Science, 311: 670-4, 2006. (Cited in 96 papers) 3. S. Moeller et al., "Patches with links: a unified system for processing faces in the macaque temporal lobe," Science, 320:1355-9, 2008