In Jennifer Elisseeff's small tissue-culture room at Johns Hopkins University, she points to an eraser-sized pellet of two-layered hydrogel floating in culture medium. She explains how the cells, encapsulated within juxtaposed layers of gel, exchange signals to help them grow. Knowing what those signals are could help her design a hydrogel that would regenerate diseased tissue.
As a teenager working on a science fair project in her father's engineering lab at Florida Atlantic University, Elisseeff began to appreciate the cross-talk between biology and materials while studying the effects of bacteria on metal corrosion. After her first year of medical school in the Harvard/MIT Health Science and Technology program, Elisseeff found a way to apply her interest when she recognized a huge need in the field of orthopedic surgery. Bone and cartilage lack good natural repair mechanisms, and the surgical treatment for the damaged...
Title: Associate Professor, Department of Biomedical Engineering, Johns Hopkins University
Representative publications: 1. J. Elisseeff et al., "Transdermal photopolymerization for minimally invasive implantation," Proc Natl Acad Sci, 96:3104-7, 1999. (Cited in 127 papers) 2. J. Elisseeff et al., "Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks," J Biomed Mater Res, 51:164-71, 2000. (Cited in 123 papers) 3. N.S. Hwang et al., "Effects of three-dimensional culture and growth factors on the chondrogenic differentiation of murine embryonic stem cells," Stem Cells, 24:284-91, 2006. (Cited in 15 papers)