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Improving Preclinical Discovery of CRISPR Engineered Immune Cell Therapies
Improving Preclinical Discovery of CRISPR Engineered Immune Cell Therapies
IsoPlexis | Mar 6, 2019
There is an urgent need to characterize the potency and efficacy of CRISPR-Cas9-modified inducible pluripotent stem cell-derived natural killer cells for preclinical cancer immunotherapy research. IsoPlexis' single-cell proteomics system addresses this challenge by connecting each immune cell to cytokine secretion and thereby correlating them to in vivo outcome across a range of disease areas.
Clones Made of CRISPRed Monkeys
Clones Made of CRISPRed Monkeys
Carolyn Wilke | Jan 25, 2019
Researchers edited macaque embryos to induce symptoms of sleep disorders and chose one animal to clone. A bioethicist questions the study’s appropriateness.
CRISPR Babies Trial May Have Been Government Funded
CRISPR Babies Trial May Have Been Government Funded
Shawna Williams | Feb 25, 2019
Documents about the experiment challenge a Chinese government investigation’s finding that He Jiankui mostly acted alone.
Archaea CRISPR Systems Grab DNA Memories During Interspecies Mating
Archaea CRISPR Systems Grab DNA Memories During Interspecies Mating
Carolyn Wilke | Mar 1, 2019
When different archaeal species mate, their CRISPR systems interact in ways that may influence their evolution.
The Challenge of Using CRISPR to Knock In Genes
The Challenge of Using CRISPR to Knock In Genes
Anna Nowogrodzki | Mar 1, 2019
Researchers are developing an array of techniques for accurately and efficiently inserting genes into DNA.
Companies Use CRISPR to Improve Crops
Companies Use CRISPR to Improve Crops
Ashley P. Taylor | Feb 1, 2019
The agritech industry is editing plant genomes to feed a growing population, expand the produce aisle, and make tastier, more convenient food products.
UC Berkeley Team to Be Awarded CRISPR Patent
UC Berkeley Team to Be Awarded CRISPR Patent
Kerry Grens | Feb 11, 2019
The group had argued that a patent given to the Broad Institute overlapped with this one.
Scientist Forged Ethical Reviews for CRISPRed Babies
Scientist Forged Ethical Reviews for CRISPRed Babies
Kerry Grens | Jan 21, 2019
He Jiankui could face charges after an investigation finds he used techniques prohibited in China to edit the genes of twin girls.
The US Scientists Who Knew About CRISPRed Babies
The US Scientists Who Knew About CRISPRed Babies
Shawna Williams | Jan 29, 2019
Multiple researchers were aware of He Jiankui’s clinical trial before the news became public in November.
Off-target Effects in CRISPR-Cas9 Genome Editing: Securing Specificity
Off-target Effects in CRISPR-Cas9 Genome Editing: Securing Specificity
The Scientist Creative Services Team | Jan 24, 2019
The Scientist is bringing together a panel of experts to discuss the current understanding of how off-target effects may limit the applications of Cas9-mediated genome modification

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