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Opinion: Test Brain-Reviving Technology in Infants First
Opinion: Test Brain-Reviving Technology in Infants First
John D. Loike, Alan Kadish | Jul 9, 2019
If a system tested in decapitated pigs ever gets to human clinical trials, neuroscientific and ethical reasons point to testing babies before adults.
Opinion: How to Define Life
Opinion: How to Define Life
John D. Loike, Robert Pollack | May 2, 2019
As artificial life forms become more sophisticated, we propose a simple list of criteria to determine whether synthetic biological organisms and robots are living beings.
Opinion: Ethical Challenges in Using iPS Cells to Treat Paralysis
Opinion: Ethical Challenges in Using iPS Cells to Treat Paralysis
John D. Loike, Martin Grumet | Mar 7, 2019
Uncertainties about the cells’ risk profiles and the potential for hyping unproven therapies mean scientists and the media must tread carefully.
Opinion: Ethical Boundaries Needed on the Uses of Synthetic DNA
Opinion: Ethical Boundaries Needed on the Uses of Synthetic DNA
John D. Loike, Robert Pollack | Mar 1, 2019
A newly expanded genetic alphabet that includes four synthetic nucleotides highlights the need for strict boundaries on their use.
Genome Editing on Board
Genome Editing on Board
Bob Grant | Jan 1, 2019
2018 closed with hubbub surrounding the purported birth of babies whose genomes had been edited using CRISPR. What will 2019 hold for CRISPR’s use in humans?
Opinion: The Central Dogma of Mitochondrial Genetics Needs Rewriting
Opinion: The Central Dogma of Mitochondrial Genetics Needs Rewriting
John D. Loike | Dec 12, 2018
The recent discovery of 17 people who have inherited maternal and paternal lines of mitochondrial DNA has major ramifications for medical and ancestry research.
Opinion: Don’t Ban the Use of CRISPR in Embryos
Opinion: Don’t Ban the Use of CRISPR in Embryos
John D. Loike | Nov 29, 2018
Despite a premature and ethically sketchy claim of genome editing in twin girls, an outright prohibition could blunt promising, responsible progress.
Opinion: The New Frontiers of Epigenetics
Opinion: The New Frontiers of Epigenetics
John D. Loike | Nov 12, 2018
Newly developed techniques could propel a field already advancing rapidly to complement modern medicine.
Opinion: Consumer DNA Testing Is Crossing into Unethical Territories
Opinion: Consumer DNA Testing Is Crossing into Unethical Territories
John D. Loike | Aug 16, 2018
Data don’t support many direct-to-consumer products, from telomere assessments to bespoke diets based on genetic sequences.
Opinion: Three-Parent Embryos—A Slippery Slope?
Opinion: Three-Parent Embryos—A Slippery Slope?
John D. Loike, Alan Kadish | Jun 14, 2018
The use of pronuclear transfer to treat infertility must first be backed by evidence it can work in cases where parents seek to avoid mitochondrial mutations.

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