This webinar, brought to you by Miltenyi Biotec, will be hosted live and available on-demand.
Wednesday, October 14, 2026
2:00 - 3:00 PM ET
Legacy persistent organic pollutants, including dioxins and dioxin-like compounds, remain detectable in the environment at low but biologically relevant concentrations and have been associated with metabolic disturbances that contribute to steatotic liver disease. These compounds are potent agonists of the aryl hydrocarbon receptor (AHR), but the AHR in mice has greater ligand affinity and responsiveness than the human receptor. These species-specific differences complicate efforts to translate experimental findings into an understanding of human hepatotoxicity.
In this webinar, Banrida Wahlang, will discuss findings from acute and sub-chronic exposure to an environmentally relevant mixture of dioxins and dioxin-like compounds in a humanized AHR model. She will examine how species-specific receptor biology and sex influence hepatic toxicity phenotypes, as well as how isolated hepatocytes can support studies of receptor-mediated signaling and activation. The presentation will highlight how these approaches improve interpretation of environmental toxicology studies and inform human health risk assessment.
Topics to be covered
- Isolation of mouse hepatocytes with gentleMACS Liver Perfusion Technology
- Species-specific differences in human and mouse AHR signaling
- Sex-specific hepatic responses to environmental toxicants
- Humanized mouse models for translational toxicology
 | Banrida Wahlang, PhD, DABT |
