Edited by: Steve Bunk
H. Dudek, S.R. Datta, T.F. Franke, M.J. Birnbaum, R. Yao, G.M. Cooper, R.A. Segal, D.R. Kaplan, M.E. Greenberg, "Regulation of neuronal survival by the serine-threonine protein kinase Akt," Science, 275:661-5, Jan. 31, 1997. (Cited in more than 245 papers since publication)

Alex Toker

Comments by Henryk Dudek, senior scientist, neurosciences group, Ontogeny Inc., Cambridge, Mass., and Michael E. Greenberg, professor of neurology, Children's Hospital, Harvard Medical School

T.F. Franke, D.R. Kaplan, L.C. Cantley, A. Toker, "Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate," Science, 275:665-8, Jan. 31, 1997. (Cited in more than 240 papers since publication)

Comments by Thomas F. Franke, assistant professor of pharmacology, Columbia University, and Alex Toker, staff scientist, signal transduction group, Boston Biomedical Research Institute

Among the most important realizations emerging from signal transduction research this decade has been the key role in...

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