Signal Transduction

S. Gupta, T. Barrett, A.J. Whitmarsh, J. Cavanagh, H.K. Sluss, B. Dérijard, R.J. Davis, "Selective interaction of JNK protein isoforms with transcription factors," EMBO Journal , 15(11):2760-70, 1996. (Cited about 90 times since publication)

Comments by Roger J. Davis, Howard Hughes Medical Institute investigator and professor of molecular biology at the University of Massachusetts Medical School in Worcester.

HANDY JNK: Howard Hughes Medical Institute's Roger Davis and colleagues learned that JNK, a member of the mitogen-activated protein kinase family, has more isoforms--and more potential therapeutic possibilities--than researchers previously thought.

JNK may be anything but what its pronunciation suggests. This protein kinase--a member of the mitogen-activated protein kinase group--has been associated with general responses to environmental stress and with pro-inflammatory cytokines. However, this paper showed that JNK is more varied--and thus potentially more useful--than previously thought.

Roger J. Davis, Howard Hughes Medical Institute Investigator and professor of biochemistry and...