Edited by: Paul Smaglik

DEATH DUEL: One TNF receptor 1 pathway activates apoptosis, another triggers gene expression-roles in seeming opposition, says David Goeddel.
H. Hsu, H Shu, M. Pan, D.V. Goeddel, "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways," Cell, 84:299-308, 1996. (Cited in more than 130 publications through November 1997)

Comments by David V. Goeddel, Tularik Inc., San Francisco

Two of the most important activities of the common cytokine tumor necrosis factor (TNF) are to signal apoptosis and to initiate NF-kappa B activation. The signaling starts at the TNF receptor 1 (TNFR1) and moves downstream in a series of biochemical reactions, which until recently were mostly unknown.

"This paper really starts to show how complex the TNF receptor 1 signaling pathway is," says David V. Goeddel, CEO of Tularik Inc., a San Francisco-based biotech company engaged in developing new pharmaceutical products....

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