Edited By: Karen Young Kreeger

STRESSED OUT: Jöel Raingeaud, left, and Roger Davis found that the p38 MAP kinase is activated by inflammatory cytokines and environmental stress.
J. Raingeaud, S. Gupta, J.S. Rogers, M. Dickens, J. Han, R.J. Ulevitch, R.J. Davis, "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine," Journal of Biological Chemistry, 270:7420-6, 1995. (Cited in nearly 100 publications as of March 1997) Comments by Roger J. Davis, University of Massachusetts Medical School, Howard Hughes Medical Institute.

The signal transduction pathways of mitogen-activated protein (MAP) kinases have been actively studied for some time. About three years ago, a new mammalian protein kinase encoded by the gene p38 was identified and cloned in Richard Ulevitch's lab at the Scripps Research Institute in La Jolla, Calif., by Jiahuai Han, a postdoctoral fellow on Ulevitch's research team (J. Han et...

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