E.M. Brown, G. Gamba, D. Riccardi, M. Lombardi, R. Butters, O. Kifor, A. Sun, M.A. Hediger, J. Lytton, S.C. Hebert, "Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid," Nature, 366:575-80, 1993. (Cited in more than 100 publications through November 1995)

Comments by Edward Brown and Steven Hebert, Brigham and Women's Hospital, Boston

This paper describes the isolation, cloning, and molecular characterization of a receptor molecule for calcium ions located on the outer surface of certain types of cells. The reason it has received so much attention from the scientific community is that "this was the first evidence that extracellular calcium ions [Ca2+] could have direct effects on certain cells via a membrane-bound receptor," declares Edward Brown, a professor of medicine in the endocrine-hypertension division of the department of medicine at Brigham and Women's Hospital and Harvard Medical School.

Hebert and Brown DIRECT EFFECTS:...

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