Solid State ChIP Technology Enables Ground Breaking Research

Chromatrap reports on 3 further customer papers published in different prestigious peer reviewed journals, which cite how its proprietary solid state Chromatin Immunoprecipitation (ChIP) technology has enabled ground breaking research. A recent study published in Drug Metabolism & Deposition [1] looks at " The role of Chromatin structural changes in regulating human CYP3A ontogeny. Variability in drug metabolizing enzyme developmental trajectories contributes to inter-individual differences in susceptibility to chemical toxicity and adverse drug reactions, particularly in the first years of life. Factors linked to these inter-individual differences are largely unknown, but molecular mechanisms regulating ontogeny are likely involved. To evaluate chromatin structure dynamics as a likely contributing mechanism, age-dependent changes in modified and variant histone occupancy were evaluated within known CYP3A4 and 3A7 regulatory domains. Results of research published in the Journal of Immunology [2] review how 'Moderate alcohol induces stress proteins HSF1 and hsp70 and inhibits pro-inflammatory cytokines resulting ...