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Training Immune Cells to Be Cancer Killers
Aparna Nathan | Nov 12, 2021
A career-altering experience as a cancer patient motivated one researcher to design more potent immunotherapies.
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Can mRNA Vaccine Momentum Propel Tumor Immunotherapies?
Aparna Nathan | Nov 12, 2021
A guide to mRNA-based cancer vaccines and where they’re headed next
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Precision Medicine Turns to Proteins for Lung Cancer Targets
Roni Dengler, PhD | Nov 9, 2021
Probing the protein landscape in lung cancers reveals new therapeutic insights.
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Trapped Inflammatory Molecules Contribute to Long COVID
Roni Dengler, PhD | Nov 9, 2021
Microclots in blood plasma may be behind Long COVID’s chronic symptoms.
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Early Successes Make CRISPR-Based Medicine a Possibility
Aparna Nathan | Oct 25, 2021
CRISPR-Cas9’s molecular scissors—thus far limited to the lab bench—may soon find themselves at work directly in the human body.
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From Bench to Boardroom
Aparna Nathan | Oct 25, 2021
Taking inspiration from her PhD research, Ana Moreno formed a company where scientists use CRISPR to treat chronic pain
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How Lung Cancer Develops in People Who Have Never Smoked
Roni Dengler, PhD | Oct 8, 2021
More and more people who have never smoked tobacco are developing lung cancer. A new genomic analysis revealed that an accumulation of natural mutations led to the disease.
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Gut-Brain Axis Development Influences Brain Damage in Extremely Premature Infants
Roni Dengler, PhD | Oct 8, 2021
An overgrowth of bacteria in the gut predicted brain injury in preemies.
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A 3-D Tumor Microenvironment for Personalized Immunotherapy
Roni Dengler, PhD | Sep 10, 2021
A new platform enables screening a wide range of combination anticancer therapeutics in a matter of days, which may translate to personalized therapeutic regimens for patients in less time.
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A New Model with Fully Functioning Blood Vessels Mimics Brain Cancer
Roni Dengler, PhD | Sep 10, 2021
A newly developed platform may one day replace cell culture and animal models to personalize cancer treatment.
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Heating Up CAR T Cells for Cancer Therapy
Roni Dengler, PhD | Sep 10, 2021
Heated gold nanoparticles unleash the therapeutic activity of engineered CAR T cells.
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Fecal Transplant Restores Youth to Old Mice
Roni Dengler, PhD | Aug 30, 2021
Microbiota from young mice reversed some aspects of aging and enhanced brain health in aged mice.
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Gut Bugs May Help Centenarians Reach Their 100th Birthdays
Roni Dengler, PhD | Aug 30, 2021
Centenarians have distinct microbiomes with species that produce unique bile acids, which may help thwart illness.
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Engineered Yeast Robots Destroy Inflammatory Molecules in an IBD Mouse Model
Roni Dengler, PhD | Aug 16, 2021
Scientists added a gene circuit that senses and neutralizes proinflammatory ATP to yeast, taking another step towards precision medicine.
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Could a Synthetic Probiotic Replace a Strict Diet for Patients with Phenylketonuria?
Roni Dengler, PhD | Aug 16, 2021
Synthetic biologists introduced an engineered microbe that may lead to new treatment options for phenylketonuria.
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A New COVID-19 Spit Test Is as Easy as 1-2-3
Roni Dengler, PhD | Aug 16, 2021
A device smaller than two stacked decks of cards can reliably detect and discriminate between SARS-CoV-2 variants in spit in less than an hour with results that glow.
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How to Grow a Mouse Embryo in a Dish
Roni Dengler, PhD | Aug 3, 2021
Researchers are taking the concept of three-dimensional cell culture beyond single organoids to develop embryos from cells.
Mammary tumor organoids undergo a radical shape shift when treated with a microRNA.
Organoid Shape Identifies Potential Cancer Drugs
Roni Dengler, PhD | Aug 3, 2021
An unusual drug screen takes advantage of “porcupine-like” structures of cancer cells in 3D organoids.
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AI Helps Predict Winners and Losers in Clinical Trials
Roni Dengler, PhD | Aug 3, 2021
Pradipta Ghosh has plans to revolutionize the drug discovery pipeline.
Undone Proteins Take Out Bladder Cancer
Roni Dengler, PhD | Jul 20, 2021
An unfolded protein found in human milk shows promise in early clinical trials to treat bladder cancer.