VAI
One Sequence, Many Variations
Van Andel Institute | Oct 5, 2022 | 5 min read
Andrew Pospisilik explores the epigenetic changes that give organisms the plasticity to change in response to their environments.
Medical illustration depicting self-renewal of a single stem cell dividing into two identical cells.<br><br>
Brush Up: What Is Stemness and Pluripotency?
Deanna MacNeil, PhD | Sep 30, 2022 | 4 min read
Scientists study pluripotent stems cells to understand early development and how to use them in regenerative medicine, disease modeling, and drug discovery.
A full blood sample vial lying on top of a piece of paper that reads &ldquo;Acute lymphoblastic leukemia&rdquo;.
Targeting Leukemia with T Cells That Avoid Self-Destruction
Deanna MacNeil, PhD | Sep 26, 2022 | 3 min read
Researchers found that naturally-occurring CD7-negative T cells avoid self-destruction and are good effectors in CAR T therapy for T cell blood cancers.
A wrecking ball destroying a malignant cell as a 3D illustration
Armored CAR T Cells Break Through Immune Suppression in Solid Tumors
Jennifer Zieba, PhD | Sep 26, 2022 | 3 min read
Researchers determined the safety and antitumor ability of genetically engineered CAR T cells that circumvent immune suppression in a prostate cancer phase I clinical trial.
jigsaw puzzle with magnifying glass over the word &quot;metastasis&quot;&nbsp;
Breast Cancer Cells Retrain T Cells to Invade Specific Tissues
Nele Haelterman, PhD | Sep 26, 2022 | 3 min read
Scientists discover tumor-associated T cells that drive breast cancer metastasis to lymph nodes.
Chromatogram peaks of a DNA sequencing analysis.
Brush Up: What Is Bisulfite Sequencing and How Do Researchers Use It to Study DNA Methylation?
Deanna MacNeil, PhD | Sep 15, 2022 | 4 min read
Prior to DNA methylation sequencing, researchers treat their samples with sodium bisulfite to distinguish methylated cytosine from unmethylated cytosine.
Mammoth Extinction
Finding The Cause of Mammoth Extinction
Sejal Davla, PhD | Sep 7, 2022 | 3 min read
Environmental DNA and climate change data suggest that vegetation scarcity led to the mass extinction of herbivore species, including Arctic mammoths.
Dog Ancestry Provides Clues to Ancient Human Activities
Dog Ancestry Provides Clues to Ancient Human Activities
Niki Spahich, PhD | Sep 1, 2022 | 3 min read
Researchers combined evidence found in dog genomes with physical materials recovered from archeological sites to discover factors behind major societal changes.
A nude (hairless) mouse, typically used in biomedical and drug discovery research methods that rely on immunodeficient mouse strains.
Brush Up: Humanized Mice: More than the Sum of Their Parts
Deanna MacNeil, PhD | Aug 31, 2022 | 5 min read
Scientists study human health in vivo with modified mice that molecularly mimic human biology.
Ancient Mummies&rsquo; Lousy View of the Past
Ancient Mummies’ Lousy View of the Past
Nele Haelterman, PhD | Aug 25, 2022 | 3 min read
Researchers develop method to study ancient human DNA preserved by head lice.
Small Changes, Big Consequences
Small Changes, Big Consequences
Niki Spahich, PhD | Aug 23, 2022 | 3 min read
To understand the mechanisms behind severe COVID-19, researchers identified common COVID-19 genetic risk variants that affect immune cell function.
Uncovering Leprosy&rsquo;s Genetic Recipe for Success
Uncovering Leprosy’s Genetic Recipe for Success
Nele Haelterman, PhD | Aug 17, 2022 | 3 min read
Researchers identify what makes certain people more likely to contract leprosy than others.
GENETIC PREDISPOSITION TO VITAMIN D DEFICIENCY CONTRIBUTES TO SEVERE COVID-19
Genetic Predisposition to Vitamin D Deficiency Contributes to Severe COVID-19
Iris Kulbatski, PhD | Aug 15, 2022 | 4 min read
Ana Teresa Freitas discusses how individual variation in vitamin D synthesis and metabolism influences susceptibility to upper respiratory viruses.
Mini organs in a dish
Brush Up: What Are Organoids and How Are They Made?
Jennifer Zieba, PhD | Aug 11, 2022 | 5 min read
Miniaturized, in vitro versions of organs provide insights into disease and development.
Time Traveling Mini-Brains on a Mission to Conquer Space
Time Traveling Mini-Brains on a Mission to Conquer Space
Iris Kulbatski, PhD | Aug 11, 2022 | 4 min read
Alysson R. Muotri discusses his launch of brain organoids into outer space and how microgravity enriches our understanding of brain development and disease.
in love with the shape of you
In Love with the Shape of You: Physical Scaffolding Defines Organoid Patterning
Sejal Davla, PhD | Aug 8, 2022 | 3 min read
Controlling a growing tissue’s shape achieves deterministic and uniform patterning in intestinal organoids.
COVID-19 vaccine vials
COVID-19 Vaccines Induce Better Long-Term Immunity than Infection
Jennifer Zieba, PhD | Aug 8, 2022 | 3 min read
For the first time, researchers performed a head-to head longitudinal study comparing the immune response elicited by mRNA and traditional COVID-19 vaccines to primary infections.
An abstract stained-glass portrait of a woman with an image of an eye representing the brain
Through the Looking Glass: Aging, Inflammation, and Gut Rejuvenation
Iris Kulbatski, PhD | Aug 8, 2022 | 4 min read
Renewing the aging gut microbiome holds promise for preventing inflammatory brain and eye degeneration.
Motor neurons, undergoing degeneration in ALS
Mutant T Cells That Drive Amyotrophic Lateral Sclerosis (ALS) Progression May React To a Brain Antigen
Nele Haelterman, PhD | Aug 8, 2022 | 4 min read
Scientists discovered a possibly autoreactive T cell population that forecasts and supports disease progression.