The Next Frontier in Disease Modeling

Mouse strains with a variety of functional human immune systems empower clinically relevant research.

The Jackson Laboratories
Oct 9, 2015

View poster here: JPG | PDFTHE JACKSON LABORATORIES

Empowering Clinically Relevant Modeling Using NSGTM
 

NOD scid gamma (NSGTM), a highly immunodeficient mouse only available from The Jackson Laboratory, provides the unmatched ability to model normal and malignant tissues and cells notoriously difficult to engraft and study in other mouse strains, including:

  • Hematopoietic stem cells (hu-NSGTM)
  • Patient-derived xenografts (PDX)
  • PDX-bearing hu-NSGTM for immuno-oncology research

JAX® offers humanized NSGTM and NSGTM-based strains with additional manipulations of the host (including the NSGTM-SGM3 strain that expresses the human cytokines IL-3, GM-CSF, and SCF) for an enhanced ability to recapitulate specific functions of human disease in vivo. These humanized NSGTM strains have superior T cell- and B cell-dependent immune responses, antibody production, and myeloid engraftment.

PDX-engrafted NSGTM mice from our In Vivo Pharmacology Services are early passage to maintain tumor structure fidelity and cellular heterogeneity that...

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The Next Frontier in Disease Modeling

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