MilliporeSigma: Dialfiltration vs. Dialysis

Diafiltration and dialysis can be used to exchange buffer in different ways. Learn more about when to use each in the video below.

The Scientist Creative Services Team
Nov 21, 2019

Dialysis is the passive removal of solutes using a semipermeable membrane whereas dialfiltration is the forced exchange of buffer using pressure. Diafiltration also concentrates samples, but it isn't suitable for every sample. To learn more, visit

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