neuroscience

Autophagy and Mitophagy in Neurodegeneration: A Deep Dive

Robin Ketteler and Hélène Plun-Favreau discuss the importance of autophagy and mitophagy regulation in neurodegenerative diseases.

This webinar will be hosted live and available on-demand

Tuesday, September 27, 2022 
11:00 AM Eastern Time (8:00 AM PT)

Cell growth, proliferation, and survival are tightly regulated processes. Defects in this regulatory control can lead to autophagy and mitophagy—the breakdown of cells and mitochondria, respectively—leading to severe diseases, including neurodegenerative disorders such as Parkinson’s disease.

In this webinar brought to you by PerkinElmer, Robin Ketteler and Hélène Plun-Favreau will discuss the importance of understanding autophagy and mitophagy for identifying potential neurodegenerative disease therapeutic targets.

Topics to be covered: 

  • Therapeutic drug discovery strategies utilizing CRISPR genome editing
  • Leveraging high-content imaging to maximize identification of potential therapeutics
  • What rare, Mendelian forms of Parkinson’s disease teaches us about the biology of PINK1-dependent mitophagy
  • Applying the learnings about the biology of mitophagy and high throughput screening to better understand the genetics of the more common, sporadic forms of Parkinson’s disease

Robin Ketteler, PhD
Professor
Laboratory for Molecular Cell Biology (LMCB)
University College London

Hélène Plun-Favreau, PhD
Professor
University College London


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