After a period of uncontrolled proliferation, subsets of primary tumor cells undergo functional phenotypic changes that increase migration and drive metastasis. This webinar sponsored by IsoPlexis will discuss how a unique synergistic paracrine signaling pathway promotes cell migration and causes cancer cells to break away from a tumor and spread throughout the body. Denis Wirtz will highlight how discovering metastasis initiators by cytokine profiling helped researchers develop a potential therapy that inhibits metastasis and improves cancer patient outcomes.
Topics to be covered
- How cell density and proliferation affect tumor cell metastasis and how they shape the development of novel therapies
- How cytokine profiling and highly multiplexed proteomic analysis of three-dimensional models help identify proteins encouraging cell migration
- How identifying a potential mechanism promoting tumor cell migration enables the development of a strategy...
Meet the Speakers:
Denis Wirtz, PhD
Vice Provost for Research
TH Smoot Professor, Chemical and Biomolecular Engineering, Pathology, Oncology
Director, Johns Hopkins Physical Sciences-Oncology Center
Johns Hopkins University and Johns Hopkins School of Medicine