Viral fusion with the cell membrane is essential for infection by enveloped viruses. For BSL4 (biosafety level 4) human pathogens such as the deadly Nipah virus (NiV), mechanistic studies of the fusion process are particularly challenging, as cell-cell fusion assays do not fully recapitulate the variables of viral entry into cells. In this webinar, our panelist will describe how his lab uses flow cytometry and surrogate virus particles to transform technical and biosafety challenges into a new model for study of virus-cell fusion. Following the presentation, attendees will have an opportunity to ask questions concerning their research and receive answers in real-time.
Topics to be covered:
- The global health implications of elucidating viral entry strategies of zoonotic RNA viruses
- The advantages of flow virometry, a novel use of flow technology yielding high-throughput measurement of viral composition and conformational changes in viral glycoproteins
- New techniques for modeling the entry of enveloped...
Meet the Speaker:
Dr. Hector Aguilar-Carreno
Paul G. Allen School for Global Animal Health
Washington State University