High-Throughput Screening of GPCRs for Drug Discovery Applications

G protein-coupled receptors (GPCRs) are membrane-bound signaling proteins that play an important role in clinical medicine. Mutations in GPCRs have been implicated in a variety of human diseases and they constitute the largest class of protein targets for pharmacological manipulation. However, technical challenges persist in the rapid screening of GPCR agonists and antagonists. The Scientist brings together a panel of experts to discuss advances in high-throughput screening for GPCR drug discovery. Attendees will have an opportunity to interact with the experts, ask questions, and seek advice on topics related to their drug discovery research.

Topics to be covered:

• Case studies highlighting screening and assay development of small-molecule antagonists for GPCRs
• High-throughput screening for Gq-coupled receptors using fluorescence-based detection of second messengers
• High-throughput screening hit selection and compound profiling for GPCRs

Meet the Speakers:

Dr. Edward Ainscow
Director
Genomics Institute of the Novartis Research Foundation

Sylvie Jezequel-Sur, MS
Associate...