Approximately 40% of human diseases may be attributable to defects in the cellular proteostasis machinery, including the ubiquitin-proteasome system. Accumulation of misfolded, damaged, or aggregated proteins can lead to prolonged stress, accumulation of reactive oxygen species, and cell death. In this webinar, brought to you by Bio-Techne, Jennifer Johnston will discuss how her research of ubiquitin-proteasome system elements, including Parkin E3 ligase, is used to diagnose and treat diseases caused by defects in proteostasis pathways.
Topics to be covered
- The basics of the ubiquitin-proteasome system
- The biology and druggability of ubiquitin E3 ligases
- Modifications of ubiquitin proteins and their therapeutic and diagnostic applications
Meet the Speaker:
Jennifer Johnston, PhD
Cofounder and CEO