Characterizing the mass of proteins and their complexes has a wide range of applications. However, the large degree of heterogeneity present in some biological systems have historically posed a near-unsurmountable challenge to traditional native mass spectrometry and classic structural biology techniques. To overcome this, researchers are turning to new, single-particle mass analysis methods. In this webinar brought to you by Refeyn, Victor Yin, a postdoctoral researcher of biomolecular mass spectrometry and proteomics at Utrecht University, will discuss how mass photometry and charge detection mass spectrometry enable the study of several challenging protein systems, including the interaction of full antibodies with SARS-CoV-2.
Topics to be covered
- Comparison of mass photometry and charge detection mass spectrometry as methods to study protein interactions in complex, heterogeneous systems
- Single-particle mass analysis of intact, megaDalton ribosomes
- New insights into how full-length antibodies interact with the SARS-CoV-2 spike protein trimer
Meet the Speaker:
Victor Yin, PhD
Biomolecular Mass Spectrometry and Proteomics