Strategies for the Rapid Assessment of Antibody Self-Interactions and Improved Formulations Development

Martin Domnowski explains how sequence and formulation affect antibody self-interaction properties, and how researchers detect these interactions in low concentration samples.

The Scientist Creative Services Team and Sartorius
Feb 2, 2022

LIVE Webinar

Wednesday, March 16, 2022
10:00 AM Eastern Time (3:00 PM CET)

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An antibody's increased tendency to bind itself at high concentrations limits its stability. As such, scientists must carefully characterize self-interaction when selecting molecules for pharmaceutical applications. However, researchers often have only scarce sample amounts during early-stage development, which prevents them from using many self-interaction analysis methods. Techniques to assess antibody self-interactions with only micrograms of protein are urgently needed.

In this webinar, brought to you by Sartorius, Martin Domnowski, a former researcher at the Ludwig Maximilian University of Munich, will discuss how Bio-Layer Interferometry (BLI) quickly and reliably identifies antibodies with a strong tendency for self-interaction. Moreover, he will present mitigation strategies for reducing antibody self-interaction, such as specific formulation excipients and rational mutagenesis.

Topics to be Covered

  • Antibody self-interaction in pharmaceutical drug development
  • Using Octet® BLI technology for monoclonal antibody formulation development
  • Identifying antibody variants with lower self-interaction tendencies

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Meet the Speakers:

Martin Domnowski, PhD
Pharmaceutical Technology and Biopharmaceutics
Ludwig Maximilian University

David Apiyo, PhD
Manager of Applications Scientists
BioAnalytics Applications