Systems immunology is a new and rapidly developing field of research providing quantitative molecular profiles of patients' immune responses, made possible by recent advances in multiple technological platforms. The human-centered approach has invigorated vaccine research and shown promise to enhance our knowledge of the systemic immune response to vaccination and infection that was not possible with classical, animal-model based approaches. Techniques that make use of peripheral blood to survey systemic immune responses include next-generation sequencing coupled to bioinformatic analysis, gene and protein microarrays, metabolomics, multiparameter flow cytometry, mass cytometry, and multiplex cytokine and chemokine assays. The Scientist is bringing together a panel of experts to present their research in systems immunology and provide insight into this exciting new field.
Topics to be covered:
- New insights into immune responses to infection through data-driven analysis of multiplexed single-cell data
- Using systems immunology to understand innate immune dysfunction in HIV infection
Meet the Speakers:
Associate Professor, Dept. of Biomedical Engineering
Dept. of Molecular, Cellular, and Developmental Biology
Assistant Professor, Department of Health Sciences