3D cell culture

3D-rendered cross section of an animal cell, signifying the importance of cellular environment in directed evolution—proteins intended for use in human cells should not be evolved in bacteria or yeast.

Protein Evolution in Mammalian Cells May Improve Therapeutics

By Andrea Lius, PhD | | 4 min read

Bridging Advanced 3D Cell Culture and Real-World Discovery

Advanced 3D Cell Models: Bridging the Gap to Therapeutic Effect

Available on Demand

Building New Approach Methodologies and Complex In Vitro Assays

Building New Approach Methodologies and Complex In Vitro Assays

Available on Demand

Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

Available on Demand

3D illustration of an antibody, displaying surface structure and internal domains

Tools for the Next Generation of Therapeutic Research

By Bio X Cell and The Scientist | | 3 min read

The image depicts a lung cancer tri-culture model made with RASTRUM Allegro. Primary normal human lung fibroblasts (NHLFs) were printed with primary human umbilical vein endothelial cells (HUVECs) and A549 lung adenocarcinoma cells using RASTRUM’s Imaging Model architecture. Cells were cultured for 7 days and stained using a PhenoVue Cell Painting Kit (Revvity). Cell nuclei (cyan) were labeled with Hoescht, filamentous actin (yellow) with phalloidin, and membrane glycoproteins (magenta) with concanavalin A.

3D Cell Culture: The Future of Research and Drug Discovery

By The Scientist and Inventia Life Science | | 6 min read

Fluorescence microscopy image of a human small intestine organoid stained with Ki67 and EpCAM antibodies and DAPI (scale bar represents 100 micrometers).

Capturing Cancer Complexities with Tumor Organoid Cultures

By Sino Biological and The Scientist | | 3 min read

A photo of cell culture flasks stacked in an incubator, each filled with culture medium.

Navigating the Complexities of Cell Culture

By Baker | | 1 min read

Cluster of blue cells encasing green tube structures.

The Era of Organoids: Disease Modeling, Developmental Research, and Drug Response Prediction

By Rebecca Roberts, PhD | | 4 min read

Multicolored microscopy image of a blood generating-heart forming organoid on a black background, showing the various cell types that make up the organoid.

Scientists Get to the Heart of Blood Formation

By Iris Kulbatski, PhD | | 4 min read

Learn How 3D Cell Cultures Advance Tissue Regeneration

Organoids as a Tool for Tissue Regeneration Research

By The Scientist | | 1 min read

Studying Organ Development and Disease Using Organoids

Studying Organ Development and Disease Using Organoids

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Image of Nobel Prize medal on a table.

Who Will Win the 2026 Nobel Prize? Scientists Make Their Predictions

From GLP-1 pioneers to researchers who uncovered the genetic roots of narcolepsy, scientists reveal who they think could receive a call from the Nobel Committee this year.

A photograph of a rattlesnake against a jungle-like background.

Vipers’ Self-Defense Mechanism Could Spark a New Antivenom Strategy

Toxin-inhibiting proteins evolved by rattlesnakes protected mice from lethal venom doses and showed activity against toxins from some other vipers.

Sex-Specific Dioxin Toxicity in a Humanized AHR Model

Sex-Specific Dioxin Toxicity in a Humanized AHR Model

Explore how species-specific aryl hydrocarbon receptor signaling and biological sex influence hepatic responses to environmentally relevant dioxin exposure and inform human health risk assessment.

Alt-Text A conceptual image of blue histograms on a graph gradually increasing in size up toward the right with a trendline following.

Federal Research Grant Awards Fall to a Six-Year Low

An independent grant tracker's analysis of NIH's own award records shows the agency has issued fewer grant awards this fiscal year than in any of the past six.

Multimedia

Evaluating Blood Biomarkers for Alzheimer’s Disease Staging

Evaluating Blood Biomarkers for Alzheimer’s Disease Staging

Explore how blood-based biomarkers perform across Alzheimer’s disease stages, including AIBL Study findings comparing p-Tau217 and other markers against amyloid-beta and tau PET reference standards.

Three-dimensional illustration of a curved, single-stranded RNA molecule against a blue background

Gene Editing Precision Depends on Guide RNA Quality

Reduce synthesis-related impurities and support target recognition with gRNA purification

The Scientist October Digest cover

October 2026

Antarctica’s Blood Falls Teems With Mysterious Microbial Life

Miles away from the closest ocean, marine microbes thrive in the red ice and mud around Blood Falls, offering clues to microbial adaptation and past climate events.

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Evaluating Blood Biomarkers for Alzheimer’s Disease Staging

Evaluating Blood Biomarkers for Alzheimer’s Disease Staging

Explore how blood-based biomarkers perform across Alzheimer’s disease stages, including AIBL Study findings comparing p-Tau217 and other markers against amyloid-beta and tau PET reference standards.

Find better biologics faster with Stunner and the AI Developability Workcell

Find better biologics faster with Stunner and the AI Developability Workcell

Learn how microvolume UV/Vis and DLS can accelerate, automate, and streamline protein developability screening while reducing sample requirements.

An image of microcentrifuge tubes arranged within colorful laboratory racks.

Choose clarity. Choose speed. Choose MyMass™

Assess protein sample purity and homogeneity in minutes with mass photometry using only nanograms of sample.

Characterizing LNP Heterogeneity With Super-Resolution Imaging

Characterizing LNP Heterogeneity With Super-Resolution Imaging

Explore how super-resolution microscopy enables particle-level characterization of lipid nanoparticle composition, cargo loading, heterogeneity, and stability, providing complementary insights for formulation development and optimization.

Products

Product News

Stellaromics Expands Pyxa Adoption as Instruments are Installed at Leading Research Institutions Across the U.S. and EuropeStellaromics, Inc., the leader in 3D

The placements follow the commercial launch of Pyxa at the Advances in Genome Biology and Technology (AGBT) meeting in February 2026 and mark the company's transition from Early Access into global commercial availability.

A monoclonal antibody surrounded by immune cells and red blood cells

CellRaft AIR: Find the Right Antibody-Producing Cells Faster

The CellRaft AIR streamlines antibody discovery with imaging, functional screening, and gentle isolation of viable single B cells and hybridomas, helping verify monoclonality and identify high producing clones faster.

Maxwell® Rapid ccfDNA Kit

Maxwell® Rapid ccfDNA Kit: Automated Purification of ccfDNA in Under 30 Minutes

Load plasma directly into prefilled cartridges, no pretreatment, no ethanol. Under 30 minutes of instrument run time, up to 48 samples in parallel, with a high-throughput format also available.

Leica Biosystems, Tempus, and Paige logos side by side, marking the addition of Paige digital pathology AI tools to the Aperio AI Store.

Oncology Researchers Gain AI Cancer Tools in One Platform

Two Paige tools, powered by the Virchow pathology foundation model, are now available within a single image management workspace for oncology research.