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Breaking the Cancer-Obesity Link
Laura W. Bowers, Stephen D. Hursting, Ciara H. O’Flanagan | Nov 1, 2015
Obese people are at higher risk for developing cancer, have worse prognoses once diagnosed, and are often resistant to chemotherapy regimens. The question is, Why?
A Complex Disorder
Stephen D. Hursting, Ciara H. O’Flanagan, Laura W. Bowers | Nov 1, 2015
Factors that likely contribute to obesity include disruptions to intercellular signaling, increased inflammation, and changes to the gut microbiome.
Warming Up to Brown Fat
Kerry Grens | Oct 8, 2015
Scientists know how to turn on these fat-combusting cells. Can these energy burners be used to combat obesity?
Neuronal Connection Between Fat and the Brain Visualized
Anna Azvolinsky | Sep 24, 2015
Researchers pinpoint the neurons within white fat tissue that mediate brain-bound leptin signaling and eventual fat breakdown.
Burn Victims Produce Brown Fat
Kerry Grens | Aug 7, 2015
Following extreme trauma, patients’ adipose samples have revealed—for the first time in humans—that white fat can be converted into energy-burning brown fat.
Bone Marrow Makes New Fat Cells
Ashley P. Taylor | Jul 16, 2015
The origins of adipocytes have been hotly debated, but a human study supports the idea that the bone marrow takes part.
Brain’s Role in Browning White Fat
Anna Azvolinsky | Jan 15, 2015
Insulin and leptin act on specialized neurons in the mouse hypothalamus to promote conversion of white to beige fat.
Week in Review: October 6–10
Jef Akst | Oct 10, 2014
Nobel Prizes awarded; transgenerational effects of mitochondrial mutations; fat-targeted gene knockdown; Ebola updates in Spain and U.S.
Next Generation: Fat-Targeted Gene Knockdown
Molly Sharlach | Oct 5, 2014
A small peptide helps a silencing construct home in on the adipocytes of obese mice.
Markers Distinguish “Good” from “Bad” Fat
Anna Azvolinsky | Jul 30, 2014
Researchers have identified three fat cell-specific surface markers that distinguish white from brown and beige adipocytes.