Blue 3D illustration of X-shaped chromosomes
X Chromosome Silenced in Some Cancers in Males
Natalia Mesa | Nov 11, 2022 | 3 min read
A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males. 
fluorescently labeled microscopy cross-section of bone
Cancer Cells in Mice May Hitch a Ride with Bone-Healing Stem Cells
Andy Carstens | Nov 7, 2022 | 4 min read
Researchers have long observed a connection between bone metastasis and remodeling, which might be due to a close connection between the two cell types. 
Breaking Down Barriers: Cell Therapy for Solid Tumors
The Persistence of (T Cell) Memory: Towards Cellular Therapy for Solid Tumors
The Scientist Creative Services Team | 1 min read
In this webinar, Douglas Green will describe how early events in T cell activation influence anti-tumor immunity. 
Pink- and purple-stained cells clustered into glands
Phenotypic Variation in Cancer Cells Often Not Due to Mutations
Jef Akst | Oct 26, 2022 | 3 min read
Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 
two glowing neuronlike macrophages
Immune Cells Imitating Neurons Cause Pain in Mice with Tumors
Shafaq Zia | Oct 18, 2022 | 3 min read
Whether the finding of a novel mechanism for cancer-related pain can lead to better treatments for neuropathic pain in people remains to be seen.
A mole-rat poses in the grass 
The Scientist Speaks - Exploring the Secrets to Longevity and Cancer Resistance in Mole-Rats
The Scientist Creative Services Team | 1 min read
Vera Gorbunova discusses what naked and blind mole-rat cells reveal about aging and cancer resistance mechanisms. 
A purple-stained section of an invasive breast cancer growth. The dark purple non-fatty tissue takes up the majority of the frame, and pale purple circular tumors grow in ducts in the bottom left.
Harboring Hard and Soft Cells Lets Tumors Grow and Metastasize Simultaneously
Katherine Irving | Oct 17, 2022 | 4 min read
Islands of rigid cells within a matrix of soft ones allow tumors to be both solid and fluid, granting them toughness without losing the ability to break apart.
A vet and technician take a sample from a dog for use in PetDx’s OncoK9 test, which screens cell-free DNA for genomic alterations associated with cancer.
The Pet Health Industry Takes on Canine Cancer
Diana Kwon | Oct 17, 2022 | 10+ min read
Advanced genomic tools have provided biotech companies new approaches to help our furry friends—but experts say several limitations remain.
Lipid nanoparticle delivers treatment to a cancer cell.
Researchers Develop a CRISPR-Based Therapy That Penetrates Solid Tumors
Jennifer Zieba, PhD | 3 min read
By packaging lipid nanoparticles with elements that decrease the fibrous nature of solid tumors, researchers can deliver CRISPR therapies in a more efficient manner.
exterior of Fred Hutch research building
Fred Hutch Receives $710 Million Gift from the Bezos Family
Shawna Williams | Oct 13, 2022 | 1 min read
The donation will fund recruitment, research facilities, clinical research, and immunotherapy research.
Happy woman surrounded by children
Pediatric Oncologist Audrey Evans Dies at 97
Lisa Winter | Oct 12, 2022 | 3 min read
Evans advanced the field of pediatric cancer treatment and cofounded the first Ronald McDonald House in 1974 to help families with sick children.
A full blood sample vial lying on top of a piece of paper that reads “Acute lymphoblastic leukemia”.
Targeting Leukemia with T Cells That Avoid Self-Destruction
Deanna MacNeil, PhD | 3 min read
Researchers found that naturally-occurring CD7-negative T cells avoid self-destruction and are good effectors in CAR T therapy for T cell blood cancers.
outline of a brain slice with white patch surrounded by teal
Astrocytes Feed Glioblastoma, Promoting Tumor Growth: Mouse Study
Patience Asanga | Oct 5, 2022 | 3 min read
Starving glioblastoma tumors of the cholesterol made by astrocytes could suppress brain cancer progression.
Grayscale microscopic image of dying melanoma cells
Science Snapshot: Living Bubble Wrap
Lisa Winter | Oct 5, 2022 | 1 min read
This year’s fourth-place winner of the 2022 Nikon Small World in Motion competition shows dying melanoma cells.
A wrecking ball destroying a malignant cell as a 3D illustration
Armored CAR T Cells Break Through Immune Suppression in Solid Tumors
Jennifer Zieba, PhD | 3 min read
Researchers determined the safety and antitumor ability of genetically engineered CAR T cells that circumvent immune suppression in a prostate cancer phase I clinical trial.
Illustration of intestine containing pink microbes
Fungal DNA, Cells Found in Human Tumors
Catherine Offord | Sep 30, 2022 | 2 min read
It’s not clear whether, or how, the organisms might play a role in disease pathology.
illustration of blue cells with exosomes budding off of them and floating away
Nanoparticles Spur Mouse Immune System to Attack Cancer
Shafaq Zia | Sep 13, 2022 | 2 min read
A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  
jigsaw puzzle with magnifying glass over the word "metastasis" 
Breast Cancer Cells Retrain T Cells to Invade Specific Tissues
Nele Haelterman, PhD | 3 min read
Scientists discover tumor-associated T cells that drive breast cancer metastasis to lymph nodes.
Histological slide showing cancerous prostate tissue
2D Genetic Map of Prostate Cells Charts Cancer Growth
Holly Barker | Aug 23, 2022 | 4 min read
An in situ map of copy number variations in prostate tissue reveals that purportedly cancerous genomic changes frequently occur in the healthy tissue surrounding tumors.
Fluorescent microscopy of a healthy intestinal organoid and a tumor spheroid
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Shafaq Zia | Aug 19, 2022 | 3 min read
Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.