line illustration of DNA with single-strand break
Cancer Cells Break Own DNA to Defend Against Radiation
Sophie Fessl | Apr 28, 2022
Self-inflicted DNA breaks let the cells hit pause on repair of radiation-induced DNA damage, giving them time to recover, an in vitro study shows.
Illustration of light blue speckled DNA helix on a dark background
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Jef Akst | Apr 22, 2022
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.
chipcytometry-tissue
Revolutionizing Cellular Phenotyping with Multiplex Tissue Imaging
The Scientist Creative Services Team, Canopy Biosciences | May 9, 2022
Highly multiplexed tissue immunohistochemistry combined with an automated, high resolution imaging pipeline resolves unlimited protein targets in intact tissue.  
Dark red cancer cells travel through the circulatory system alongside small, brighter-colored red blood cells
Traversing Narrow Channels Helps Metastatic Cancer Cells Survive
Dan Robitzski | Apr 14, 2022
In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.
Tiled blue-gray MRI readouts of a human brain.
Cancer Tied to Reduced Risk of Alzheimer’s Disease
Dan Robitzski | Apr 14, 2022
Observational evidence for the connection is solidifying, and some clues are emerging about the mechanisms that may explain it.
Human DNA stock photo
Setting Better Traps for PARP Inhibitors
The Scientist Creative Services Team, BPS Bioscience | Apr 19, 2022
An innovative assay permits researchers to screen for small molecule PARP inhibitors that trap the enzyme on DNA and selectively execute cancer cells.
Artist’s rendering of multiple natural killer cells, colored light pink, attacking a purple tumor cell.
Protein Pilfered from Cancer Cells Thwarts Immune Attack
Dan Robitzski | Apr 13, 2022
New research in mice reveals why natural killer cells, normally effective at hunting cancer, are sometimes stopped in their tracks.  
illustration of a blood vessel
Bacteria in Tumors Promote Metastasis in Mice
Sophie Fessl | Apr 7, 2022
Microbes living inside cancer cells may help them spread to distant sites by enhancing the cells’ resistance to mechanical stress, a study shows.
Visualize Transcript Location with Spatial Biology Techniques
Unraveling the Cellular and Subcellular Landscape Using Spatial Biology
The Scientist Creative Services Team, Resolve Biosciences | Apr 12, 2022
How to visualize gene expression patterns in situ
Diffuse star-like shapes with regions in purple, green, and both colors overlapped.
Tumor Cells on Brink of Death May Trigger Metastasis
Alejandra Manjarrez | Mar 25, 2022
A new study reports that human colon cancer cells at imminent risk of death can instead develop characteristics needed to colonize new parts of the body.
A stained tissue sample of metastatic pancreatic cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Amanda Heidt | Mar 24, 2022
Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.
Dogs under blanket together stock photo
A Nose by Any Other Name: Tracking the Scent of Tumor Metabolic Waste
Iris Kulbatski, PhD | Apr 11, 2022
The unique odor profiles of tumors can be used to develop diagnostic sensing tools.
Man in lab coat sitting at a lab bench looking at small, stoppered beaker.
Cancer Researcher Donald Pinkel Dies at Age 95
Natalia Mesa | Mar 18, 2022
Unsatisfied by how treatments for childhood leukemia failed to prevent the disease’s return, Pinkel combined them all—and virtually cured the disease.
Abstract composition of design object with lines and spheres
Notable Science Quotes
The Scientist Staff | Mar 16, 2022
Reviving the Cancer Moonshot, disentangling the microbiome's effect in cancer, the observer effect, and more
Abstract Genetics Disease stock photo
Bridging Disciplines to Study CRISPR-Induced Chromosome Destabilization
Aparna Nathan | Apr 8, 2022
A collaboration between friends led to a cautionary finding about CRISPR’s effect on cells.
Tumor microbiome composite
Could Cancer’s Microbiome Help Diagnose and Treat the Disease?
Jef Akst | Mar 14, 2022
A growing appreciation of the bacterial assemblages that live within tumors has researchers striving to understand and capitalize on their role.
Illustration showing microbial signatures of cancer in the body
Infographic: Putting Cancer’s Unique Microbiomes to Use
Jef Akst | Mar 14, 2022
From diagnosis to tracking treatment responses, bacteria and other microbes in the blood, gut, and tumors of cancer patients may provide helpful hints for improving their care.
Engineered Bacteria Make Tumors More T Cell-Friendly
Engineered Bacteria Make Tumors More T Cell-Friendly
Aparna Nathan | Apr 8, 2022
Microbes designed to produce specific immunomodulatory metabolites could give immunotherapy a boost.
illustration of blue cancer cell extending tendrils around itself
Janus-Faced Neutrophils
Sophie Fessl | Mar 2, 2022
The immune cells facilitate healing, but they may also help tumors metastasize to the lungs after injury, a study in mice finds.
A photo of a triple-negative breast cancer cell
A Fasting-Mimicking Diet Thwarts Breast Cancer in Mice
Devin A. Reese | Mar 1, 2022
Coupling a diet low in calories, sugar, and protein with existing cancer drugs treats triple-negative breast cancer in mice, and low blood glucose is associated with better cancer outcomes in human patients.