cancer

Researchers unravel the mystery of epithelial to mesenchymal transition in acute lymphoblastic leukemia with co-culture techniques, CRISPR-screening, and RNA sequencing.

Scientists established an epigenetic mouse model for glioma, providing insight into how epigenetics can initiate cancer.

This year’s Breakthrough Prizes honor advances in CAR T cancer therapies, cystic fibrosis, and Parkinson’s disease.

Researchers took aim at mucins, glycoproteins that protect cancer cells from drugs and the immune response, and engineered a revolutionary targeted tool for oncology and beyond.

A new mouse model shows that the Myc protein has complex effects on aging and cancer.

Researchers connect a tumor’s leading edge transcriptional profile to poor survival outcomes across cancer types. 

Using a mouse model of breast cancer brain metastasis, researchers showed that tumor cells require fatty acid synthesis to grow, which offers a potential therapeutic target.

Researchers turn to high resolution sequencing to explain recurrent melanoma mutations caused by UV exposure.

Researchers built a 3D glioblastoma model to study therapeutic resistance and improve drug screening systems.

Multispecific antibodies are rising stars in the field of antibody therapeutics, offering better specificity, targeting ability, and therapeutic effects than traditional monoclonal antibodies.

Tumors overexpress certain genes to survive a growing pile of harmful mutations, a trait that scientists could exploit to target with drugs.

Algorithms can now glean ever more molecular and genetic information from images of stained tissue, but some researchers worry that we can’t follow their logic.

Khalid Shah engineers stem cells to deliver cancer therapeutics directly to tumors, thereby increasing their efficacy.

Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.