black-and-white brain scan showing tumor
Glioblastoma Cells Imitate Immature Neurons to Invade the Brain
Sophie Fessl | Aug 5, 2022
Neuron-like glioblastoma cells are the pioneers of deadly tumors’ spread through the brain, contributing to their devastating invasiveness, a study in mice finds.
Artist’s 3D rendering of malignant cancer cells, illustrated in pink, as it would appear under a scanning electron microscope.
Underdog Enzyme Likely Responsible for Mutations in Most Cancers
Sophie Fessl | Jul 28, 2022
A previously overlooked enzyme called APOBEC3A is linked to the most prevalent mutational signatures in cancer cell lines, a study finds.
3d illustration proteins with lymphocytes , t cells or cancer cells
New Patient Tumor Cell Models Rapidly Predict Cancer Therapy Outcomes
Jennifer Zieba, PhD | Jul 11, 2022
A new benchtop microfluidic device generates patient-derived tumor micro-organospheres that allow for real-time cancer therapy decisions.
An illustration of a mitochondrion, represented by a purple and orange bilayer, synthesizing reddish molecules of ATP.

Mitochondrial Protein Fuels Spread of Head and Neck Cancer 

Patience Asanga | Jul 8, 2022
Head and neck cancer cells lacking the peptide involved in energy production were less likely to metastasize in mice.
Illustration of two weaving proteins 
Fusion with Spider Silk Increases Anti-Cancer Protein’s Stability
Dan Robitzski | Jul 5, 2022
Scientists found that combining the notoriously flimsy anti-cancer protein p53 with a domain from a spider silk protein resulted in a more stable hybrid that’s more potent and easier for cells to synthesize.
 Discover the latest technologies for oncopathology
Broadening Tumor Molecular Profiling Horizons
The Scientist Creative Services Team, Canopy Biosciences | Jun 28, 2022
From histopathology to multiplex immunohistochemistry and spatial transcriptomics, learn how to obtain the appropriate profiling depth to match cancer classification needs.
Artist’s rendition of metastatic cancer cells with yellow nuclei and green cell bodies extending into blue tendrils.
While the Body Rests, Breast Cancer Spreads More Aggressively
Alejandra Manjarrez | Jun 23, 2022
More cancer cells are shed from primary tumors when individuals are asleep than when they’re awake, according to observations in mouse models and a small cohort of breast cancer patients.
A small, brown mouse runs on a narrow, miniature treadmill
How Exercise Helps Mice Fight Pancreatic Cancer
Dan Robitzski | Jun 15, 2022
A study reveals a molecular pathway linking exercise to an amped-up immune response to pancreatic cancer and greater responsiveness to treatment.
spatial CRISPR screen for cancer
A Brave New World for Spatial Genomics in Cancer Research
Nele Haelterman, PhD | Jun 27, 2022
A new CRISPR screening technology allows scientists to recreate tumor heterogeneity in vivo and study how it affects all aspects of cancer biology.
3D rendering of a scanning electron micrograph of pink malignant cancer cells against a black background
Cancers Ramp Up Overall mRNA Expression as They Progress
Dan Robitzski | Jun 14, 2022
A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.
Trichaptum abietinum growing on a pine log
Caught on Camera
The Scientist Staff | Jun 13, 2022
See some of the coolest images recently featured by The Scientist
3-D image of a tumor
Cancer Cells Go Incognito to Cause Therapy Relapse
Niki Spahich, PhD | Jun 27, 2022
Dormant cancer cells and dysfunctional immune cells living together in a tumor niche form a therapy-resistant reservoir.
Illustration of a crowd of people wearing protective masks
Once More Unto the Breach
Bob Grant | May 31, 2022
Notes from my first in-person mega-conference in two years
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
Reinvigorating the Immune System to Attack Cancer Cells Using Highly Specific Antibodies
Reinvigorating the Immune System to Attack Cancer Cells Using Highly Specific Antibodies
Fortis Life Sciences | Jun 20, 2022
Cancer immunotherapy targets the tumor microenvironment, blocking the molecular pathways that tumors exploit to prevent immune cell activity.
salmonella bacteria 3d illustration
Salmonella Injection Helps the Mouse Immune System Kill Tumors
Dan Robitzski | May 16, 2022
Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.
Illustration showing how following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano- particles near tumors in mice.
Infographic: Salmonella Shuttle Tumor Antigens to Immune Cells
Dan Robitzski | May 16, 2022
Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.
Discover how counterflow centrifugation streamlines cell therapy workflows
Closed Cell Processing Systems for Cell Therapy Workflows
The Scientist Creative Services Team, Thermo Fisher Scientific | Jun 16, 2022
Closed systems increase cell therapy manufacturing process efficiency.
line illustration of DNA with single-strand break
Cancer Cells Break Own DNA to Defend Against Radiation
Sophie Fessl | Apr 28, 2022
Self-inflicted DNA breaks let the cells hit pause on repair of radiation-induced DNA damage, giving them time to recover, an in vitro study shows.
Illustration of light blue speckled DNA helix on a dark background
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Jef Akst | Apr 22, 2022
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.