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An artistic interpretation of CRISPR genome editing showing the cutting and changing of DNA segments.
A Small Genome Editing Nuclease Packs a Big Punch
Sahana Sitaraman, PhD | Oct 30, 2024 | 4 min read
For the past decade, scientists have relied almost exclusively on CRISPR-Cas systems for genome editing. Now, a smaller but equally efficient nuclease is here to compete. 
An illustration of a perforated grey nucleus holding colorful spaghetti-like DNA strands.
Gene Proximity to Nuclear Speckles Drives Efficient mRNA Splicing
Karen Kelley Perkins, PhD | Oct 30, 2024 | 4 min read
Nuclear architecture investigation provides insights into the role of nuclear bodies in RNA processing.
Conceptual 3D image of AI powered biopharma research and discovery, showing a microchip inside a medicinal capsule.
Transforming Biopharma Research Through Artificial Intelligence 
Sartorius | 1 min read
Learn how researchers take their drug discovery and development research to the next level with artificial intelligence.
The Swedish bridge spider on a web over a blue background.
Unraveling the Web of Proteins in Spider Silk
Kamal Nahas, PhD | Oct 29, 2024 | 4 min read
Compartmentalized protein expression in the spider silk gland provides clues to spinning more sustainable materials. 
A thermal image of a woman’s head and neck taken from the back.
Newly Found Fat Cell Uses a Different Approach to Heat the Body  
Kamal Nahas, PhD | Oct 25, 2024 | 4 min read
Single-cell sequencing unpacked 10 varieties of fat cells, including one that uses an alternative heat-regulating strategy that protects against weight gain.
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All About Alternative Splicing
Amielle Moreno, PhD | 7 min read
Enhancing protein diversity and guiding cellular functions, alternative splicing is a key dimension of genetic regulation.
3D illustration of an antibody bound to a metallic nanoparticle.
A New Approach Improves Signal Detection in Mass Cytometry
Shelby Bradford, PhD | Oct 24, 2024 | 3 min read
A team of researchers developed a technique, ACE, to improve the ability to study low-abundance proteins using mass cytometry.
Image shows a brain and a digestive system, specifically the intestines, connected by nodes. 
Gut Serotonin Curbs the Developing Immune System
Claudia Lopez-Lloreda, PhD | Oct 24, 2024 | 3 min read
In neonatal mice, the neurotransmitter serotonin mobilizes immune cells that promote tolerance to antigens.
Upgrading Cell Therapies for Cancer Treatment
Upgrading Cell Therapies for Cancer Treatment
The Scientist Staff | 1 min read
Learn how scientists address cancer cell therapy discovery and development difficulties.
A vibrant blue circle containing blue filaments and a few magenta points within it.
Ovarian Proteins That Last a Lifetime Help Maintain Egg Cells for Years
Sneha Khedkar | Oct 18, 2024 | 4 min read
Long-lived proteins in the mouse ovary may help preserve fertility well into adulthood, providing insights into ovarian aging. 
An illustration of a blue brain with the cerebellum highlighted in pink.
New Cilia Disassembly Pathway Revealed in Maturing Neurons
Charlene Lancaster, PhD | Oct 17, 2024 | 5 min read
Volume electron microscopy reveals a novel cellular process that is critical for healthy brain development, with implications for tumor formation.
Organoid Models and 3D Imaging for Parkinson’s Disease Research
Organoid Models and 3D Imaging for Parkinson’s Disease Research
The Scientist Staff | 2 min read
In this webinar, scientists will discuss the advantages of assembloid models and the fundamentals of imaging 3D neuronal architecture. 
Jotham Austin, the advanced electron microscopy core director at the University of Chicago, stands in the facility beside an EM instrument, helping a student who is sitting at the computer.
Career Chat: Choosing a Core Career Track
Shelby Bradford, PhD | Oct 17, 2024 | 5 min read
Jotham Austin opted for a director of a core facility position to combine his love for electron microscopy, teaching, and technique development.
An African killifish 
How Cells Know Where to Grow After Injury
Deanna MacNeil, PhD | Oct 16, 2024 | 3 min read
Fish fins and single-cell sequencing help scientists glean new insights into tissue regeneration.
Winning Westerns: Tips and Tricks for Protein Electrophoresis and Western Blotting
Winning Westerns: Tips and Tricks for Protein Electrophoresis and Western Blotting
The Scientist Staff | 1 min read
In this webinar, Kelly Wolfe will highlight how to obtain more reliable and reproducible western blots.
Liquid biopsy and circulating tumor cells
The Next Frontier: Circulating Tumor Cells and Liquid Biopsies
The Scientist Staff | Oct 15, 2024 | 2 min read
Improved methods for circulating tumor cell capture and analysis can ensure reproducible biomarker and omics insights across different cancer types.
Lucid Resipher Device 96-well microplate lid
A Simple Cell Culture Intervention for Healthier Cells
The Scientist Staff | Oct 15, 2024 | 2 min read
Monitoring and manipulating cell culture oxygen consumption rates enables more physiologically-relevant in vitro models.
Winning Westerns: Tips and Tricks for Protein Electrophoresis and Western Blotting
Winning Westerns: Tips and Tricks for Protein Electrophoresis and Western Blotting
The Scientist Staff | 1 min read
In this webinar, Kelly Wolfe will highlight how to obtain more reliable and reproducible western blots.
Some pills strewn about next to an alarm clock on a blue background. 
Why Timing Matters When Taking Medicines
Sneha Khedkar | Oct 10, 2024 | 4 min read
Human liver cells follow their own circadian rhythms, which regulate drug metabolism and infection.
Black and gold sketch of David Baker, Demis Hassabis, and John Jumper.<strong >&nbsp;</strong>
Nobel Prize in Chemistry for Work on Proteins
Sneha Khedkar | Oct 9, 2024 | 3 min read
David Baker, Demis Hassabis, and John Jumper share this year’s Chemistry award for their research on protein design and structure prediction.
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