Long-term administration of the antidepressant fluoxetine was tied to decreased concentrations of about 100 different brain lipids in adolescent macaques, hinting at a potential mechanism underlying the drug’s rare but severe side effects.

The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.

The methodology involves modifying histones and displaying them on the cell surface for analysis.

By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.

The researcher, known for his work on the mTOR signaling pathway, is no longer with MIT’s Whitehead Institute or HHMI following an investigation into his conduct.

Vesicles containing fragments of the organelles released from stressed adipocytes protect the heart against oxygen deprivation, a study in mice shows.

His work centered on the mechanisms of glucose transport into cells.

Engineered antibodies trap and immobilize human sperm in the reproductive tract of female sheep, paving the way for possible use as a nonhormonal contraceptive in people.

Researchers identify a protein that promotes changes in adipose tissue in vitro and in pregnant mice and may help protect against gestational diabetes in humans.

Researchers propose a mechanism by which a protein produced in the placenta may trigger blood vessel growth and enlarge fat cells.

The AlphaFold program from AI firm DeepMind has amassed a huge database of protein structures from humans and model organisms.

Loss of the protein ATG7 is fatal in mice, but not always for people—although it is linked to human neurodevelopmental disorders, researchers report.

Scientists show that an influx of noradrenaline can halt immune cells in mice.

The University of Sheffield researcher devises new protocols to gain molecular-level insights.