cell & molecular biology, ecology
Cancer Kismet
Cancer Kismet
Jenny Rood | Apr 1, 2015
Fate mapping allows researchers to follow cancer progression from its cell type of origin.
Control ALT, Delete Cancer
Control ALT, Delete Cancer
Haroldo Silva, David Halvorsen, Jeremy D. Henson | Apr 1, 2015
Treating cancer by shutting down the alternative lengthening of telomeres (ALT) pathway
Getting Your Sugar Fix
Getting Your Sugar Fix
Kate Yandell | Apr 1, 2015
A guide to glycan microarrays
Setbacks and Great Leaps
Setbacks and Great Leaps
Sue Armstrong | Apr 1, 2015
The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.
Toggling Between Life and Death
Toggling Between Life and Death
Ashley P. Taylor | Apr 1, 2015
In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.
Signaling Resistance
Signaling Resistance
Jenny Rood | Apr 1, 2015
Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.
Yvonne Saenger: Immunotherapy Pioneer
Yvonne Saenger: Immunotherapy Pioneer
Jef Akst | Apr 1, 2015
Assistant Professor, Department of Medicine, Columbia University. Age: 41
From Many, One
From Many, One
Elena E. Giorgi | Apr 1, 2015
Diverse mammals, including humans, have been found to carry distinct genomes in their cells. What does such genetic chimerism mean for health and disease?
Resisting Cancer
Resisting Cancer
George Klein | Apr 1, 2015
If one out of three people develops cancer, that means two others don’t. Understanding why could lead to insights relevant to prevention and treatment.
Short, Strong Signals
Short, Strong Signals
Ruth Williams | Mar 25, 2015
Methylation increases both the activity and instability of the signaling protein Notch.