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Over the Counter Antihistamines Could Help Against Cancer
The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.
Nov 19, 2021
Cell Diversity Could Spell Trouble for Animal Models of Cancer
Characterizing Proteolysis During SARS-CoV-2 Infection
A Guide for High-Throughput Screens with Pluripotent Stem Cells
A Lab-Stage mRNA Vaccine Targeting Ticks May Offer Protection Against Lyme and Other Tick-Borne Diseases
Andaleeb Sajid | Nov 18, 2021
NIH researcher Andaleeb Sajid discusses her study’s finding that ticks were unable to feed on vaccinated guinea pigs, preventing transmission of the pathogen that causes Lyme disease.
Hope, Concern Surround WHO Green Light of First Malaria Vaccine
Katarina Zimmer | Oct 28, 2021
RTS,S has several flaws but could still save tens of thousands of lives, experts say.
A Scalable Process to Efficiently Manufacture Adeno-Associated Viral Vectors
The Scientist Creative Services Team in collaboration with Thermo Fisher Scientific | Oct 28, 2021
An optimized AAV production system allows researchers to consistently generate high virus titers.
How Commensal Gut Bacteria Keep Pathogens in Check
Alejandra Manjarrez | Oct 14, 2021
Recent studies describe how resident microbiota appear to outcompete unwelcome visitors, either with superior weaponry or by guzzling up local resources.
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Jef Akst | Oct 12, 2021
Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.
From Bench to Boardroom
Aparna Nathan | Oct 25, 2021
Taking inspiration from her PhD research, Ana Moreno formed a company where scientists use CRISPR to treat chronic pain
Antiviral Pill Lowers Risks of COVID-19 Hospitalization, Death
Chloe Tenn | Oct 1, 2021
Merck reports that its antiviral molnupiravir was effective against early stages of COVID-19 in high-risk patients in a Phase 3 clinical trial.
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Sruthi S. Balakrishnan | Oct 1, 2021
Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.
High-Throughput Solutions for Lead Candidate Discovery
Thermo Fisher Scientific | Oct 18, 2021
New technologies allow researchers to scale up assays for cellular functions.
Book Excerpt from
You Bet Your Life
Paul A. Offit | Sep 21, 2021
In his book’s Introduction, physician-scientist Paul A. Offit reviews the unusual constellation of circumstances around the development of COVID-19 vaccines.
Opinion: An Alternative to Injection
Carmine D’Amico, Hélder Santos | Sep 9, 2021
Research on microneedle patches for vaccine delivery has grown in popularity in recent years, due to their exceptional compliance and low invasiveness.
High-Quality Screening and Target Validation During Drug Development
The Scientist Creative Services Team in collaboration with Thermo Fisher Scientific | Oct 18, 2021
Drew Adams will discuss his work developing therapeutics that promote remyelination for neurological diseases.
Updated Nov 17
Lawmakers Request Information About Alzheimer’s Drug Approval
Annie Melchor | Sep 3, 2021
The FDA granted the drug, called Aduhelm, accelerated approval earlier this summer in a process that’s since drawn scrutiny.
Low Frequency Electric Stimulation Can Treat Back Pain: Study
Emma Yasinski | Sep 2, 2021
Patients in a small trial said their chronic pain improved an average of 90 percent over the course of 15 days, but returned shortly after the electrical stimulation sessions ended.
Focus on Structure to Verify Protein Function
The Scientist Creative Services Team in collaboration with RedShiftBio | Oct 6, 2021
Scientists analyze a therapeutic protein’s secondary structure to confirm drug efficacy and safety.
Tool Would Use Tumor Gene Expression to Inform Radiation Dose
Alejandra Manjarrez | Aug 27, 2021
In a retrospective analysis, a team found that an algorithm integrating the gene expression of a tumor with the radiation dose a patient received predicted how well the patient responded to the treatment.
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena | Aug 18, 2021
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
A New Model with Fully Functioning Blood Vessels Mimics Brain Cancer
Roni Dengler, PhD | Sep 10, 2021
A newly developed platform may one day replace cell culture and animal models to personalize cancer treatment.
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Amanda Heidt | Aug 12, 2021
The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.
Antibodies Stop Sperm in Their Tracks
Abby Olena | Aug 11, 2021
Engineered antibodies trap and immobilize human sperm in the reproductive tract of female sheep, paving the way for possible use as a nonhormonal contraceptive in people.