black-legged deer tick waits on leaf for host to feed on
A Lab-Stage mRNA Vaccine Targeting Ticks May Offer Protection Against Lyme and Other Tick-Borne Diseases
Andaleeb Sajid | Nov 18, 2021
NIH researcher Andaleeb Sajid discusses her study’s finding that ticks were unable to feed on vaccinated guinea pigs, preventing transmission of the pathogen that causes Lyme disease.
close-up of a mosquito on human skin
Hope, Concern Surround WHO Green Light of First Malaria Vaccine
Katarina Zimmer | Oct 28, 2021
RTS,S has several flaws but could still save tens of thousands of lives, experts say.
illustration of colorful microbes inside a person's stomach and intestines
How Commensal Gut Bacteria Keep Pathogens in Check
Alejandra Manjarrez | Oct 14, 2021
Recent studies describe how resident microbiota appear to outcompete unwelcome visitors, either with superior weaponry or by guzzling up local resources.  
Illustration of neurons in white with myelin in blue
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Jef Akst | Oct 12, 2021
Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.
Merck research facility in San Francisco
Antiviral Pill Lowers Risks of COVID-19 Hospitalization, Death
Chloe Tenn | Oct 1, 2021
Merck reports that its antiviral molnupiravir was effective against early stages of COVID-19 in high-risk patients in a Phase 3 clinical trial.
Brain cells with electrical firing. 3D rendering.
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Sruthi S. Balakrishnan | Oct 1, 2021
Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.
a pill bottle with dice spilling out
Book Excerpt from You Bet Your Life
Paul A. Offit | Sep 21, 2021
In his book’s Introduction, physician-scientist Paul A. Offit reviews the unusual constellation of circumstances around the development of COVID-19 vaccines.
A microneedle patch on a fingertip
Opinion: An Alternative to Injection
Carmine D’Amico, Hélder Santos | Sep 9, 2021
Research on microneedle patches for vaccine delivery has grown in popularity in recent years, due to their exceptional compliance and low invasiveness.
Updated Nov 17
Photograph of the US Food and Drug Administration’s sign outside their offices in Washington, D.C.
Lawmakers Request Information About Alzheimer’s Drug Approval
Annie Melchor | Sep 3, 2021
The FDA granted the drug, called Aduhelm, accelerated approval earlier this summer in a process that’s since drawn scrutiny.
two doctors looking at a medical monitor showing electrodes being inserted near a person's spinal cord
Low Frequency Electric Stimulation Can Treat Back Pain: Study
Emma Yasinski | Sep 2, 2021
Patients in a small trial said their chronic pain improved an average of 90 percent over the course of 15 days, but returned shortly after the electrical stimulation sessions ended.
A medical linear accelerator used to deliver radiation therapy
Tool Would Use Tumor Gene Expression to Inform Radiation Dose
Alejandra Manjarrez | Aug 27, 2021
In a retrospective analysis, a team found that an algorithm integrating the gene expression of a tumor with the radiation dose a patient received predicted how well the patient responded to the treatment.
Red blood vessels that decrease in diameter as they radiate outward are pictured on a pink and white surface
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena | Aug 18, 2021
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
An artistic rendering of blue neurons against a white background
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Amanda Heidt | Aug 12, 2021
The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.
A grayscale electron micrograph shows hundreds of sperm cells stuck together in the foreground
Antibodies Stop Sperm in Their Tracks
Abby Olena | Aug 11, 2021
Engineered antibodies trap and immobilize human sperm in the reproductive tract of female sheep, paving the way for possible use as a nonhormonal contraceptive in people.