drug development, immunology, ecology
Antibody Combo Expands Response to Checkpoint Inhibitor in Mice
Antibody Combo Expands Response to Checkpoint Inhibitor in Mice
Kerry Grens | Apr 16, 2018
Genetic analyses uncover cellular hallmarks of bladder cancer tumors that don’t respond, but interfering with one of those characteristics in a mouse model causes tumors to shrink.  
New Ovarian Cancer Vaccine Shows Promise
New Ovarian Cancer Vaccine Shows Promise
Catherine Offord | Apr 12, 2018
A preliminary clinical trial finds that the personalized therapy improves survival rates and has no severe side-effects.
Some Antibiotics Rev Up Host Immune Response to Viruses
Some Antibiotics Rev Up Host Immune Response to Viruses
Shawna Williams | Apr 9, 2018
The antimicrobial drug neomycin protects mice from some viral infections, complicating the picture of the relationship between antibiotics and susceptibility to viruses.
Opinion: We Have Been Naive About Naive T Cells
Opinion: We Have Been Naive About Naive T Cells
Jos├ę A.M. Borghans, Femke van Wijk, Theo van den Broek | Apr 6, 2018
Human naive T cells are far more heterogeneous than has long been appreciated, having implications for vaccine strategies.
Ruth Nussenzweig, Malaria Researcher, Dies
Ruth Nussenzweig, Malaria Researcher, Dies
Jim Daley | Apr 5, 2018
The microbiologist’s research led to the development of the first human malaria vaccine.
Bowhead Whales Impress Researchers With Their Song Diversity
Bowhead Whales Impress Researchers With Their Song Diversity
Catherine Offord | Apr 4, 2018
A group of around 300 whales produced 184 distinct songs over just a few years, according to a new study.
Bioengineers Use Yeast to Manufacture Drugs
Bioengineers Use Yeast to Manufacture Drugs
Jim Daley | Apr 3, 2018
The yeast’s output of noscapine, a cough suppressant naturally made by poppies, is 18,000-fold higher than previous attempts.
PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers
PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers
Vicki Brower | Apr 1, 2018
With three recent FDA approvals, and a number of Phase 3 trials ongoing, the drugs are seeing a surge in interest.
Boosting Immunotherapy Treatments in Mouse Colon Cancer
Boosting Immunotherapy Treatments in Mouse Colon Cancer
Jim Daley | Apr 1, 2018
Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.
Chromosomal Instability Drives Cancer Metastasis
Chromosomal Instability Drives Cancer Metastasis
Jim Daley | Apr 1, 2018
In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.