drug development
Sex Differences in Opioid Analgesia: A Complicated Picture
Sex Differences in Opioid Analgesia: A Complicated Picture
Catherine Offord | Jan 1, 2018
Researchers are beginning to tease apart the mechanisms underlying differences in how males and females respond to powerful painkillers.
Frog Skin Yields Potent Painkillers, but None Clinic Ready
Frog Skin Yields Potent Painkillers, but None Clinic Ready
Shawna Williams | Jan 1, 2018
Decades after their discovery by bioprospectors, amphibian-derived analgesics continue to attract scientific attention.
Sea Anemone Toxin Could Treat Autoimmunity
Sea Anemone Toxin Could Treat Autoimmunity
Jef Akst | Jan 1, 2018
If successful, the treatments could alleviate patients’ pain by reducing inflammation.
Sourcing Painkillers from Scorpions’ Stings
Sourcing Painkillers from Scorpions’ Stings
Abby Olena | Jan 1, 2018
Compounds in the arachnids’ venom interact with ion channels to both cause and block pain.
Toxin from a Dangerous Fish Delicacy
Toxin from a Dangerous Fish Delicacy
Kerry Grens | Jan 1, 2018
In tiny doses, the pufferfish’s tetrodotoxin can be turned into a pain-relieving ion channel blocker.
Mining Spider Toxins for Analgesic Clues
Mining Spider Toxins for Analgesic Clues
Catherine Offord | Jan 1, 2018
Arachnids harbor a plentiful array of molecules that target mammalian pain receptors.
Researchers Mine Centipede Toxins for Analgesics
Researchers Mine Centipede Toxins for Analgesics
Catherine Offord | Jan 1, 2018
Venomous centipedes may harbor a clue to the creation of a successful pain-killing compound for humans.
Novel Analgesics at a Snail’s Pace
Novel Analgesics at a Snail’s Pace
Bob Grant | Jan 1, 2018
Studying cone snail venom has yielded novel pain pathways, but the peptides that function as toxins are difficult to translate into drugs.
Animal Analgesics
Animal Analgesics
The Scientist Staff | Jan 1, 2018
A cornucopia of toxins in the animal kingdom could provide inspiration for novel painkillers, but so far, effective drugs have proven elusive.
 
Snake Venoms Cause and Block Pain
Snake Venoms Cause and Block Pain
Kerry Grens | Jan 1, 2018
Painful snake bites may hold clues to developing analgesic drugs.